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Gene Information
Gene symbol: IL12A
Gene name: interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35)
HGNC ID: 5969
Synonyms: CLMF, IL-12A, p35, NFSK
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CSF2 | 1 hits |
| 2 | IFNG | 1 hits |
| 3 | IL13 | 1 hits |
| 4 | IL18 | 1 hits |
| 5 | IL23A | 1 hits |
| 6 | IL4 | 1 hits |
| 7 | IL5 | 1 hits |
| 8 | NFKBIZ | 1 hits |
| 9 | STAT4 | 1 hits |
| 10 | TBX21 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 17611223 | Thus, the Th1 cytokines IL-12 (Il12), interferon gamma (INFgamma; also known as Ifng) and Tnfalpha are downregulated concomitantly with the upregulation of the Th2 cytokines IL-4, IL-13 and IL-5 (Il5) as epithelial cells commit to the luminal lineage. |
| 2 | 20876105 | Analysis of Nfkbiz(-/-) mice revealed that I?B? was essential for the production of IFN-? production and cytotoxic activity in NK cells in response to IL-12 and/or IL-18 stimulation. |
| 3 | 20876105 | IL-12/IL-18-mediated gene induction was profoundly impaired in Nfkbiz(-/-) NK cells. |
| 4 | 20876105 | Whereas the phosphorylation of STAT4 was normally induced by IL-12 stimulation, STAT4 was not recruited to the Ifng gene regions in Nfkbiz(-/-) NK cells. |
| 5 | 20876105 | I?B? was recruited on the proximal promoter region of the Ifng gene, and overexpression of I?B? together with IL-12 activated the Ifng promoter. |
| 6 | 20038794 | We used a mouse model of acute kidney ischemia-reperfusion injury (IRI) to test the hypothesis that early production of IL-23 and IL-12 following IRI activates downstream IL-17 and IFN-gamma signaling pathways and promotes kidney inflammation. |
| 7 | 21307296 | We show that IL-12 stimulation removes H3K27 trimethylation modifications at Tbx21/T-bet leading to enhanced T-bet expression with in vitro Th17 cells. |
| 8 | 21516112 | Here we report that interleukin 23 (IL-23) and the transcription factor ROR?t drove expression of the cytokine GM-CSF in helper T cells, whereas IL-12, interferon-? (IFN-?) and IL-27 acted as negative regulators. |
| 9 | 21176971 | IFNB, IL1B and IL12 were slightly increased with PCV2 infection and IFNA and IL4 were significantly downregulated. |