- About
- Home
- Introduction
- Statistics
- Programs
- Dignet
- Gene
- GenePair
- Help & Docs
- Documents
- Help
- FAQs
- Links
- Acknowledge
- Disclaimer
- Contact Us
Gene Information
Gene symbol: SOCS1
Gene name: suppressor of cytokine signaling 1
HGNC ID: 19383
Synonyms: SOCS-1, SSI-1, JAB, TIP3, Cish1
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CCL2 | 1 hits |
| 2 | CCL7 | 1 hits |
| 3 | HGF | 1 hits |
| 4 | IFNG | 1 hits |
| 5 | IL5 | 1 hits |
| 6 | IL6 | 1 hits |
| 7 | MET | 1 hits |
| 8 | TBX21 | 1 hits |
| 9 | TNF | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 20027288 | Consistent with our hypothesis, RWE challenge concurrently upregulated Th1-associated early target genes of the Il12/Stat4 pathway, such as p47 and p65 GTPases (Iigp, Tgtp and Gbp1), Socs1, Cxcl9, Cxcl10 and Gadd45g with the Th2 genes Il4, Il5, Ccl2 and Ccl7. |
| 2 | 21130166 | We found that transgene expression of SOCS-1 rendered the islets significantly more resistant to cytokine-induced cell death after treatment with TNF-alpha alone and in combination with IFN-gamma. |
| 3 | 21518797 | In this study, we first identify Socs1, Socs3, and Tcf7 (TCF-1) as gene targets that are negatively regulated by T-bet. |
| 4 | 21703184 | The regenerating liver of Socs1(-/-)Ifng(-/-) mice did not show increased IL-6 signaling, but displayed earlier phosphorylation of Gab1, a signaling adaptor downstream of c-Met. |
| 5 | 21703184 | Following HGF stimulation, hepatocytes from Socs1(-/-)Ifng(-/-) mice displayed increased phosphorylation of c-Met and Gab1, cell migration and proliferation. |
| 6 | 21703184 | SOCS1 interacted with the Tpr-Met, an oncogenic form of the Met receptor. |
| 7 | 21703184 | SOCS1 attenuates c-Met signaling and thus negative regulation of HGF signaling could be an important mechanism underlying the anti-tumor role of SOCS1 in the liver. |