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Gene Information
Gene symbol: CD46
Gene name: CD46 molecule, complement regulatory protein
HGNC ID: 6953
Synonyms: TRA2.10, MGC26544, TLX
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | AR | 1 hits |
| 2 | CD4 | 1 hits |
| 3 | CEACAM5 | 1 hits |
| 4 | CXADR | 1 hits |
| 5 | ERVWE1 | 1 hits |
| 6 | IL10 | 1 hits |
| 7 | IV | 1 hits |
| 8 | PDC | 1 hits |
| 9 | SLAMF1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 9864382 | Human membrane cofactor protein (MCP, CD46) is a regulator of complement activation and also serves as a receptor for measles virus (MV). |
| 2 | 15248250 | SLAM is selectively expressed on some T and B cells and is utilised by the Edmonston strain and wild-type strains that cannot use CD46 for cell entry. |
| 3 | 16432010 | Here, it is reported that CD46 transgenic mice (MYII-strain) express CD46 in all major organs and that it functions as a receptor for rAd35 vectors. |
| 4 | 16642271 | All breast cancer lines overexpressed the measles virus receptor CD46 and supported robust viral replication, which correlated with CEA production. |
| 5 | 17641038 | Both MDCs and PDCs were found to express the primary receptor for Ad35 (CD46) but not Ad5 (coxsackie-adenovirus receptor; CAR). |
| 6 | 19212424 | The particles entered the lymphatic cells exclusively through the signaling lymphocyte activation molecule (SLAM, CD150), whereas particles pseudotyped with the MV vaccine strain glycoproteins also recognized the ubiquitous membrane cofactor protein (CD46) as receptor and had less specific cell entry. |
| 7 | 20921150 | We have previously shown that simultaneous engagement of the T cell receptor (TCR) and complement regulator CD46 on human CD4(+) T cells in the presence of interleukin-2 (IL-2) induces potent secretion of the immunomodulatory cytokine IL-10. |
| 8 | 20800630 | This study indicates that innate immune responses by Ad35 and Ad5F35 vectors are distinct even although both Ad vectors recognize human CD46 as a receptor. |
| 9 | 21502499 | Whereas rAd5 binds coxsackie-adenovirus receptor (CAR), rAd35 binds the complement regulatory protein CD46. |
| 10 | 21502499 | Our findings provide insights into the basic biology of adenoviruses and indicate that CD46 binding may have an impact on the generation of primary CD4(+) T-cell responses by Ad35. |
| 11 | 21890164 | The presence of SIV gp160 as the only envelope protein on chimeric particles surface altered the cell tropism of the new virus from CD46+ to CD4+ cells. |