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Gene Information
Gene symbol: GTPBP1
Gene name: GTP binding protein 1
HGNC ID: 4669
Synonyms: GP-1, HSPC018
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | GP2 | 1 hits |
| 2 | MBTPS1 | 1 hits |
| 3 | NPC1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 21068251 | The arenavirus glycoprotein (GP) precursor GPC is processed by the cellular site 1 protease (S1P) to generate the peripheral virion attachment protein GP1 and the fusion-active transmembrane protein GP2, which is critical for production of infectious progeny and virus propagation. |
| 2 | 21866101 | Combined with the results of previous studies of GP structure and function, our findings support a model of EboV infection in which cleavage of the GP1 subunit by endosomal cathepsin proteases removes heavily glycosylated domains to expose the amino-terminal domain, which is a ligand for NPC1 and regulates membrane fusion by the GP2 subunit. |