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Gene Information
Gene symbol: HAVCR2
Gene name: hepatitis A virus cellular receptor 2
HGNC ID: 18437
Synonyms: Tim-3, TIM3, FLJ14428, TIMD3
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CD8A | 1 hits |
| 2 | IFNG | 1 hits |
| 3 | IL10 | 1 hits |
| 4 | IL2 | 1 hits |
| 5 | LAT | 1 hits |
| 6 | LGALS9 | 1 hits |
| 7 | PDCD1 | 1 hits |
| 8 | TNF | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 22052881 | Blocking galectin-9 signals to Tim-3-expressing cells using a Tim-3 fusion protein resulted in improved immune responses in WT mice. |
| 2 | 20679213 | This coexpression of Tim-3 and PD-1 was associated with more severe CD8 T-cell exhaustion in terms of proliferation and secretion of effector cytokines such as IFN-gamma, TNF-alpha, and IL-2. |
| 3 | 20679213 | Taken together, our study defines a parameter for determining the severity of CD8 T cell dysfunction and for identifying virus-specific CD8 T cells that produce IL-10, and shows that targeting both PD-1 and Tim-3 is an effective immune strategy for treating chronic viral infections. |
| 4 | 21307196 | LAT expression and increased latency correlated with increased mRNA levels of CD8, PD-1, and Tim-3. |
| 5 | 21307196 | PD-1 is both a marker for exhaustion and a primary factor leading to exhaustion, and Tim-3 can also contribute to exhaustion. |
| 6 | 21307196 | These results suggested that LAT(+) TG contain both more CD8(+) T cells and more CD8(+) T cells expressing the exhaustion markers PD-1 and Tim-3. |
| 7 | 21307196 | This was confirmed by flow cytometry analyses of expression of CD3/CD8/PD-1/Tim-3, HSV-1, CD8(+) T cell pentamer (specific for a peptide derived from residues 498 to 505 of glycoprotein B [gB(498-505)]), interleukin-2 (IL-2), and tumor necrosis factor alpha (TNF-?). |
| 8 | 21765403 | This differential sensitivity of HIV-specific CD8(+) T cells to T(reg) cell-mediated suppression correlates with their expression of the inhibitory receptor T cell immunoglobulin domain and mucin domain 3 (Tim-3) after stimulation with their cognate epitopes. |