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Gene Information

Gene symbol: IDDM2

Gene name: insulin-dependent diabetes mellitus 2

HGNC ID: 5373

Related Genes

#	Gene Symbol	Number of hits
1	GAD2	1 hits
2	IFNG	1 hits
3	IL4	1 hits
4	INS	1 hits

Related Sentences

#	PMID	Sentence
1	11160264	In this study, we have investigated the use of plasmid DNA (pDNA) vaccination to elicit Th2 effector cell function in an Ag-specific manner and in turn prevent insulin-dependent diabetes mellitus (IDDM) in nonobese diabetic (NOD) mice. pDNA recombinants were engineered encoding a secreted fusion protein consisting of a fragment of glutamic acid decarboxylase 65 (GAD65) linked to IgGFc, and IL-4.
2	11418698	We previously demonstrated that administration of plasmid DNAs (pDNAs) encoding IL-4 and a fragment of glutamic acid decarboxylase 65 (GAD65) fused to IgGFc induces GAD65-specific Th2 cells and prevents insulin-dependent diabetes mellitus (IDDM) in nonobese diabetic (NOD) mice.
3	11418698	Exacerbation of IDDM correlated with an increased frequency of IFN-gamma-secreting CD4(+) and CD8(+) T cells in response to insulin B chain-specific peptides compared with untreated mice.
4	11418698	In contrast, treatment with pDNAs encoding insulin A chain-IgGFc and IL-4 elicited a low frequency of IL-4-secreting Th cells and had no effect on the progression of IDDM.
5	11418698	Vaccination with pDNAs encoding GAD65-IgGFc and IL-4, however, prevented IDDM.
6	11418698	These results demonstrate that insulin- and GAD65-specific T cell reactivity induced by pDNA vaccination has distinct effects on the progression of IDDM.