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Gene Information
Gene symbol: IL13RA2
Gene name: interleukin 13 receptor, alpha 2
HGNC ID: 5975
Synonyms: IL-13R, IL13BP, CD213a2, CT19
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | ADM | 1 hits |
| 2 | IL13 | 1 hits |
| 3 | JUN | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 19010904 | By cDNA microarray, we have shown that gene transfer of human and rat adrenomedullin (AM) up-regulates IL-13Ralpha2 in a human prostate tumor cell line. |
| 2 | 19010904 | The 8- to 10-fold up-regulation of IL-13Ralpha2 by rAM or AM peptide in prostate tumor cells in vitro and in vivo increased their sensitivity to IL-13PE cytotoxin consisting of IL-13 and a truncated form of Pseudomonas exotoxin. |
| 3 | 20068108 | IL-13 induced transforming growth factor-beta1 promoter activity in IL-13Ralpha2-positive tumor cells and in cells engineered to express IL-13Ralpha2 but not in IL-13Ralpha2-negative or RNA interference knockdown cells. c-Jun and c-Fos of the AP-1 family of nuclear factors were activated by IL-13 only in IL-13Ralpha2-positive cells. |
| 4 | 20068108 | These results indicate that IL-13Ralpha2 is a functional receptor as IL-13 mediates signaling in human pancreatic cancer cell lines. |
| 5 | 18795121 | The high-affinity chain of IL-13Ralpha2 may act as negative inhibitor, suppressing the action of IL-13 and helping to maintain tumor immunosurveillance. |