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Gene Information
Gene symbol: KLRK1
Gene name: killer cell lectin-like receptor subfamily K, member 1
HGNC ID: 18788
Synonyms: NKG2D, KLR, NKG2-D, CD314
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CD28 | 1 hits |
| 2 | CD4 | 1 hits |
| 3 | CD8A | 1 hits |
| 4 | FCGR3A | 1 hits |
| 5 | HSPA1A | 1 hits |
| 6 | IFNG | 1 hits |
| 7 | IL15 | 1 hits |
| 8 | MICA | 1 hits |
| 9 | MLANA | 1 hits |
| 10 | MS4A1 | 1 hits |
| 11 | P4HB | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 16040807 | The interaction of NKG2D, a stimulatory receptor expressed on natural killer (NK) cells and activated CD8(+) T cells, and its ligands mediates stimulatory and costimulatory signals to these cells. |
| 2 | 16619285 | The lectin-like stimulatory receptor natural killer group 2D (NKG2D) was up-regulated on CD8+ T cells only from wild-type mice, but not from IL-15-deficient mice. |
| 3 | 16619285 | Mechanistically, blocking NKG2D function with an mAb inhibited M. tuberculosis-directed CD8+ T cell responses in vitro. |
| 4 | 16619285 | We conclude that in addition to regulating the expansion of CD8+ T cells, IL-15 is also necessary for inducing effector mechanisms in CD8+ T cells that depend on NKG2D expression. |
| 5 | 16619285 | Hence, our results implicate IL-15 and NKG2D as promising targets for modulating CD8+ T cell-mediated protection against tuberculosis. |
| 6 | 17804754 | On a total protein basis, Taxol induced ISMMC, expanded more CD8(+) cells, activated more CD56(+) NKG2D(+) cells to produce IFN-gamma, and were more potent inducers of high T-cell receptor density Perforin(+) cells than native ISMMC and peptide E75. |
| 7 | 18828018 | The MART-1-specific T-cell clone expressed NKG-2D and was fully capable of releasing both perforin and Granzyme B. |
| 8 | 19769739 | Through this approach, we uncovered the immunogenicity of major histocompatibility chain-related protein A (MICA), which is a ligand for NKG2D, and ERp5, a protein disulfide isomerase involved in MICA shedding. |
| 9 | 18613644 | Mechanistically, we found that HSP70-mediated DC-NK cell crosstalk required cell-cell contact, which could be inhibited completely by neutralizing antibody against NK activating receptor NKG2D. |
| 10 | 18613644 | The significance of NKG2D was further corroborated by the finding that HSP70 induced the expression of an NKG2D ligand, the MHC class I chain-related protein A (MICA), on DCs; HSP70-augmented IFN-gamma release was abrogated by antibody against MICA. |
| 11 | 21816072 | LAIV inoculation enhanced expression of activating receptor NKG2D and chemokine receptor CXCR3 on peripheral blood NK cells from both nonsmokers and smokers in vitro but did not induce changes in CD16(+) NK cells or granzyme B activity in either group. |
| 12 | 21978002 | CD8?(-) NK cells were phenotypically characterized as CD3(-) CD14(-) CD20(-) CD8?(-) cells that express NK cell markers including CD16, CD56, granzyme B, perforin, NKG2D and KIR2D. |
| 13 | 21210234 | To evaluate a possible age-related expression of NKG2D in CD4+ T cells, we compared their percentage in peripheral blood from 100 elderly and 50 young adults. |
| 14 | 21210234 | CD28 expression distinguished two subsets of CD4+ NKG2D+ cells with distinct functional properties and differentiation status. |
| 15 | 21210234 | Higher frequencies of the NKG2D+ subset were accompanied with a gradual decrease of NAIVE and central memory cells, but also with a higher level of more differentiated subsets of CD4+ T cells. |