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Gene Information
Gene symbol: ACOT1
Gene name: acyl-CoA thioesterase 1
HGNC ID: 33128
Synonyms: ACH2, CTE-1, LACH2
Related Genes
Related Sentences
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PMID |
Sentence |
1 |
16428347
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Streptozotocin-induced insulin-dependent diabetes (4 wk) and fasting (=24 h) both dramatically induced cte1 and repressed acsl6 mRNA, with no significant effects on the other acsl isoforms.
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2 |
16428347
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Culturing ARCs with oleate (0.1-0.4 mM) or the PPARalpha agonists WY-14643 (1 muM) and fenofibrate (10 muM) consistently induced acsl1 and cte1.
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3 |
16428347
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Conversely, PPARalpha null mouse hearts exhibited decreased acsl1 and cte1 expression.
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4 |
16428347
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Our data expose differential regulation of acsl isoforms and cte1 in the heart, where acsl1 and cte1 are PPARalpha-regulated genes, whereas acsl6 is an insulin-regulated gene.
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