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Gene Information
Gene symbol: ACVRL1
Gene name: activin A receptor type II-like 1
HGNC ID: 175
Synonyms: HHT2, ALK1, HHT
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | ALB | 1 hits |
| 2 | GLA | 1 hits |
| 3 | NOS2A | 1 hits |
| 4 | SMAD1 | 1 hits |
| 5 | TCF7L2 | 1 hits |
| 6 | TGFBR1 | 1 hits |
| 7 | VEGFA | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 19539633 | Incubation with high glucose (HG) and glycated albumin (gAlb) induces Alk5 and raises TGFbeta secretion 3-fold without affecting Alk1 or endoglin levels. |
| 2 | 19539633 | This diabetic milieu accelerates cell proliferation, at least in part, through TGFbeta/Alk1-smad1/5 and probably involving VEGF as well as pro-migratory MMP2 downstream of Alk1. |
| 3 | 20803090 | The expressions of TCF7L2 and ALK1 were induced by advanced glycation end products (AGEs) in parallel with Smad1, phosphorylated Smad1 (pSmad1), and alpha-smooth muscle actin (?-SMA) through TGF-?1 in cultured mesangial cells. |
| 4 | 20803090 | Furthermore, TCF7L2 induced promoter activity of ALK1. |
| 5 | 20803090 | AGEs and TGF-?1 induced a marked increase in TCF7L2 expression in parallel with ALK1. |
| 6 | 20803090 | The iNOS transgenic mice (iNOS-Tgm), which developed diabetic glomerulosclerosis resembling human diabetic nephropathy, exhibited markedly increased expressions of ALK1, TCF7L2, Smad1, pSmad1, and ?-SMA in glomeruli in association with mesangial matrix expansion. |
| 7 | 21193740 | Increased glucose augmented expression of BMP-2 and BMP-4; the BMP inhibitors matrix Gla protein (MGP) and Noggin; activin-like kinase receptor (ALK)1, -2, -3 and -6; the BMP type 2 receptor; and the vascular endothelial growth factor in human aortic endothelial cells (HAECs). |