Ignet

Gene Information

Gene symbol: AHSG

Gene name: alpha-2-HS-glycoprotein

HGNC ID: 349

Synonyms: FETUA, A2HS, HSGA

Related Genes

#	Gene Symbol	Number of hits
1	ADIPOQ	1 hits
2	BMP2	1 hits
3	CRP	1 hits
4	IL6	1 hits
5	INS	1 hits
6	INSR	1 hits
7	LEP	1 hits
8	PTH	1 hits
9	TNFSF11	1 hits

Related Sentences

#	PMID	Sentence
1	19820014	Fetuin-A inhibits the insulin receptor in vitro.
2	20543523	Fetuin-A inhibits insulin receptor autophosphorylation, which is mediated by its intrinsic tyrosine kinase activity.
3	20543523	Fetuin-A concentrations were also positively correlated with serum leptin (r = 0.150, p<0.01) and negatively with adiponectin concentrations (r = -0.208, p<0.001).
4	20543523	Stepwise regression analyses confirmed that the fetuin-A concentration was independently associated with the fasting insulin level and HOMA-IR, as were body mass index, triglyceride, LDL-cholesterol, leptin and adiponectin concentrations.
5	20713686	Higher serum fetuin-A was associated with abnormal albuminuria independent of BMI, waist circumference, homeostasis model assessment of insulin resistance, blood pressure, and other determinants of albuminuria in middle-aged and elderly Chinese women with NGT.
6	20660040	The liver-secreted protein Fetuin-A is elevated in insulin resistance, is an independent predictor of type 2 diabetes and is associated with atherosclerosis.
7	20660040	Delta (?) Fetuin-A concentrations correlated with ?fasting insulin (r = 0.710; P = 0.001), ?2-h insulin (r = 0.693; P = 0.005), and HOMA-insulin resistance (r = 0.684; P = 0.001).
8	21085476	Chemerin, progranulin, fetuin-A, and RBP4, IL-6, adiponectin and leptin serum concentrations were differentially regulated among the four investigated groups but only circulating chemerin was significantly different in patients with IGT compared to those with IFG.
9	20501463	On the other hand, aortic PWV inversely correlated with fetuin-A, log PTH, haemoglobin and albumin.
10	20947626	Moreover, the magnitude of cinacalcet-induced reduction in parathyroid hormone correlated with the decrease in RR but not with changes in serum or supernatant fetuin-A.
11	20946008	Fetuin-A has been associated with insulin resistance and inversely related with vascular calcification.
12	20946008	Serum fetuin-A concentration was not associated with measures of insulin resistance or with preclinical atherosclerosis in Hispanics and NHW.
13	20199782	Therefore, the maintenance of low levels of circulating fetuin-A may be a novel mechanism contributing to enhanced insulin sensitivity with regular physical activity.
14	20716128	Arterial calcification is the result of a complex interplay between stimulating (bone morphogenetic protein type 2 [BMP-2], RANKL) and inhibitory (matrix Gla protein, BMP-7, osteoprotegerin, fetuin-A, osteopontin) proteins.
15	21087662	Ahsg has a second physiological function in regulating how insulin signals through its receptor, a transmembrane tyrosine kinase.
16	21087662	Ahsg binds to tandem fibronectin type 3 (Fn3) domains present in the 194 amino acid residue extracellular portion of the ?-subunit of the insulin receptor, distant from the high-affinity pocket formed by two complementing ?-subunits where insulin binds.
17	20185740	Both weight loss and ezetimibe plus weight loss significantly (all P < 0.05) reduced body weight, visceral and subcutaneous adipose tissues, insulin resistance and plasma triglycerides, VLDL-apoB-100, apoC-III, fetuin-A, and retinol-binding protein-4 and increased plasma adiponectin concentrations.
18	21556362	The logistic regression analysis showed that fetuin-A were associated with elevated HOMA-IR and fasting serum insulin both among the participants with or without type 2 diabetes in the full adjusted analysis.
19	21556362	Higher fetuin-A concentrations were associated with type 2 diabetes and insulin resistance in middle aged and elderly Chinese.
20	21226708	Serum AHSG correlated negatively with adiponectin (r = -0�236, P = 0�006) even after adjusting for BMI (r = -0�177, P = 0�043).
21	21226708	Serum AHSG did not correlate significantly with CRP, resistin and TNF-? concentrations.
22	21226708	Association with adipokines favours the concept that AHSG is involved in atherosclerosis more likely through metabolic pathways (insulin resistance, obesity and adipocyte dysfunction) than by inflammation in patients with post-myocardial infarction.