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Gene Information
Gene symbol: AKT1S1
Gene name: AKT1 substrate 1 (proline-rich)
HGNC ID: 28426
Synonyms: PRAS40, MGC2865, Lobe
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CRTC1 | 1 hits |
| 2 | INS | 1 hits |
| 3 | MIRN21 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 21906675 | PRAS40 is known for its ability to regulate the mammalian target of rapamycin complex 1 (mTORC1) kinase activity, possessing a key regulatory role at the cross point of signal transduction pathways activated by growth factor receptors. |
| 2 | 21906675 | Recently it has been found that PRAS40 is regulated by its upstream phosphatidylinositol 3-kinase/Akt (PI3K/Akt) which is activated by many tyrosine kinase receptors growth factors including insulin-like growth factor 1. |
| 3 | 21914810 | In 293E, insulin increased the amount of mTORC1 retrieved by the transiently expressed nonphosphorylatable 4E-BP[5A] to an extent that varied inversely with the amount of PRAS40 bound to mTORC1. |
| 4 | 21914810 | In the presence of Rheb and insulin, PRAS40 release is abolished by Akt inhibition without diminishing mTORC1 signaling. |
| 5 | 17130464 | In the present study, the effect of in vivo insulin action on phosphorylation of the PKB/Akt substrate 40 (PRAS40) was examined. |
| 6 | 17130464 | In rat and mice, insulin stimulated PRAS40-Thr246 phosphorylation in skeletal and cardiac muscle, the liver, and adipose tissue in vivo. |
| 7 | 17130464 | Phosphorylation of PRAS40 is increased by insulin in human, rat, and mouse insulin target tissues. |
| 8 | 21613227 | Interestingly, high glucose-stimulated miR-21 inactivated PRAS40, a negative regulator of TORC1. |