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Gene Information
Gene symbol: AKT2
Gene name: v-akt murine thymoma viral oncogene homolog 2
HGNC ID: 392
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | AKT1 | 1 hits |
| 2 | GSK3B | 1 hits |
| 3 | INS | 1 hits |
| 4 | IRS1 | 1 hits |
| 5 | IRS2 | 1 hits |
| 6 | LEP | 1 hits |
| 7 | RAB4A | 1 hits |
| 8 | TCF7L2 | 1 hits |
| 9 | TRIB3 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 15010337 | Thus a physiological concentration of insulin stimulated Akt-1 and Akt-2 phosphorylation in human skeletal muscle in the absence of hyperglycemia, but Akt-2 expression and stimulation appeared to be impaired in muscle of obese patients with atypical diabetes presenting with severe hyperglycemia. |
| 2 | 17028898 | In these subjects, phosphorylation of PKBalpha and PKBbeta was increased to near-maximal levels at submaximal insulin concentrations. |
| 3 | 17599861 | Insulin-activated signaling pathways and pattern of Akt-1 and Akt-2 expression and insulin-stimulated phosphorylation were analyzed in skeletal muscle biopsy specimens. |
| 4 | 18768676 | The AKT2 gene was chosen as a candidate for PCOS because its product affects glucose metabolism and mitogenic signaling, interacts with GSK3beta, and mediates cell survival in the ovary. |
| 5 | 20728450 | Expression profiling of akt2(-/-) myocardium revealed that Rab4a, a GTPase involved in glucose transporter 4 translocation and ?-adrenergic receptor (?AR) recycling to the plasma membrane, was significantly induced. |
| 6 | 20728450 | Confirmatory analysis revealed up-regulation of Rab4a mRNA and protein in akt2(-/-) myocardium. |
| 7 | 20947368 | Emphasis is given to the observation that certain combinations of whole-body Akt1 and Akt2 deficiencies reduce circulating levels of leptin and that restoration of leptin levels restores normal glucose homeostasis in diabetic Akt-deficient mice. |
| 8 | 21190014 | Despite the reduction of Trib3 expression, AKT2 activity was not increased. |
| 9 | 21190014 | These data suggest that TRIB3 inhibition improves insulin sensitivity in vivo primarily in a PPAR-?-dependent manner and without any change in AKT2 activity. |
| 10 | 21646544 | Transient down-regulation and overexpression of Akt isoforms in adipocytes demonstrated that insulin-activated PI3-kinase signals to GLUT4 primarily through Akt2 kinase, whereas Akt1 and Akt2 signal to FoxO1. |
| 11 | 21799686 | EA stimulated the expression of IRS1 and AKT2 and atropine treatment blocked the EA-induced expression of those insulin signaling proteins. |
| 12 | 21277185 | BM supplementation significantly increased IRS-2, IR ?, PI 3K and GLUT4 protein abundance in skeletal muscle, as well as phosphorylation of IRS-1, Akt1 and Akt2 when compared with HFD (P<.05 and P<.01). |
| 13 | 21532616 | Despite continued expression of Akt2 or Akt3, pAkt levels were decreased and there was evidence of reduced Akt effect on p27 in the PVPV-Akt1KO thyroids. |
| 14 | 17021050 | These data indicate distinct roles for Akt-1 and Akt-2 in muscle glucose metabolism and that moderate reductions in IRS-1 expression do not result in the development of insulin resistance in skeletal muscle in vivo. |
| 15 | 21901280 | Our results indicate that TCF7L2 binds directly to multiple genes that are important in regulation of glucose metabolism in the liver, including Pck1, Fbp1, Irs1, Irs2, Akt2, Adipor1, Pdk4 and Cpt1a. |