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Gene Information
Gene symbol: ALOX12
Gene name: arachidonate 12-lipoxygenase
HGNC ID: 429
Synonyms: 12S-LOX
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | AGT | 1 hits |
| 2 | CYP11A1 | 1 hits |
| 3 | IL12A | 1 hits |
| 4 | INS | 1 hits |
| 5 | LCN2 | 1 hits |
| 6 | PPARA | 1 hits |
| 7 | SERPINF1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 1457080 | The 12-lipoxygenase product, 12-hydroxyeicosatetraenoic acid (12-HETE) caused a 2-fold increase in P-450(11) beta levels without altering P-450SCC levels. |
| 2 | 8275971 | The 12-lipoxygenase (LO) pathway of arachidonic acid plays an important role in angiotensin II (AII)-mediated aldosterone synthesis. |
| 3 | 8282345 | These results suggest that 12-lipoxygenase activation plays a key role in Ang II-induced vascular smooth muscle cell hypertrophy. |
| 4 | 7840166 | The acute inhibitory effects of insulin were in part mediated by inhibition of the 12-lipoxygenase pathway. |
| 5 | 9374757 | We also examined whether the 12-lipoxygenase (12-LO) product 12-hydroxyeicosatetraenoic acid (12-HETE) can alter VEGF expression, since 12-LO products of arachidonic acid have angiogenic properties, and ANG II as well as high glucose (HG, 25 mM) can increase 12-LO activity and expression in VSMC. |
| 6 | 21081706 | Sitagliptin also reduced adipocyte mRNA expression of inflammatory genes, including IL-6, TNF?, IL-12(p35), and IL-12(p40), 2.5- to fivefold as well as 12-lipoxygenase protein expression. |
| 7 | 21228311 | Only rMCs and astrocytes showed increased VEGF expression by 12-HETE. 12-LOX and its product HETE are important regulators of retinal NV through modulation of VEGF and PEDF expression and could provide a new therapeutic target to prevent and treat ischemic retinopathy. |
| 8 | 20068130 | On the other hand, the expression and activity of 12-lipoxygenase, an enzyme responsible for metabolizing arachidonic acid, and the production of tumor necrosis factor-alpha (TNF-alpha), a critical insulin resistance-inducing factor, are largely inhibited by lipocalin-2 deficiency. |
| 9 | 20068130 | Lipocalin-2 deficiency protects mice from developing aging- and obesity-induced insulin resistance largely by modulating 12-lipoxygenase and TNF-alpha levels in adipose tissue. |
| 10 | 20107107 | The hypothesis that 4-hydroxydodeca-(2E,6Z)-dienal (4-HDDE), the peroxidation product of 12-lipoxygenase, mediates this downregulatory mechanism by activating peroxisome proliferator-activated receptor (PPAR) delta was investigated. |