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Gene Information
Gene symbol: ANPEP
Gene name: alanyl (membrane) aminopeptidase
HGNC ID: 500
Synonyms: LAP1, gp150, p150
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | ADIPOQ | 1 hits |
| 2 | ADIPOR1 | 1 hits |
| 3 | ADIPOR2 | 1 hits |
| 4 | AKT1 | 1 hits |
| 5 | ANGPT1 | 1 hits |
| 6 | COL1A1 | 1 hits |
| 7 | IL6 | 1 hits |
| 8 | PREB | 1 hits |
| 9 | STAT3 | 1 hits |
| 10 | TAC1 | 1 hits |
| 11 | TEK | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 21916932 | This review focuses on the regulatory mechanisms of adiponectin (APN) gene expression during physiologic conditions and both the clinical significance and underlying molecular mechanisms of hypoadiponectinaemia during pathologic conditions. 2. |
| 2 | 17603262 | It was also revealed that proline-specific peptidases and aminopeptidase N cooperatively degrade collagen for the uptake of amino acids as nutrition when these bacteria infect cells. |
| 3 | 17607322 | Tissue expression of APM1, AdipoR1 and AdipoR2, tissue concentration of adiponectin (ApN), and metabolic variables. |
| 4 | 18436850 | CD13 (aminopeptidase N) expression in pericytes was determined by Western blot analysis and Ang effects verified with Tie-2 antisense treatment. |
| 5 | 18436850 | Ang-1 enhanced CD13 expression in a dose-dependent manner (P < 0.05) and stimulated pericyte migration in a synthetic matrix wound-healing assay that was associated with a change in F-actin organization. |
| 6 | 19382911 | In the cells expressing or knocking down the PREB, ApN expression was determined. |
| 7 | 19382911 | The nuclear extract contained ApN promoter-binding activity that was super-shifted by PREB antiserum in EMSA studies. |
| 8 | 19382911 | A deletional analysis of the ApN promoter showed that the PREB-responsive cis-element in the ApN promoter mediated the transcriptional effect of PREB, whereas a mutant of this motif in the ApN promoter abrogated the effect of PREB, as well as that of cAMP. |
| 9 | 19382911 | Furthermore, cells expressing or knocking down PREB exhibited decreased and increased ApN expression, respectively. |
| 10 | 19940263 | In WT mice, RSG (7 days) significantly increased adipocyte APN expression, elevated plasma APN levels (2.6-fold), reduced infarct size (17% reduction), decreased apoptosis (0.23 + or - 0.02% versus 0.47 + or - 0.04% TUNEL-positive in remote nonischemic area), attenuated oxidative stress (48.5% reduction), and improved cardiac function (P<0.01). |
| 11 | 21912612 | Plasma and cardiac APN levels were decreased in diabetic rats accompanied by decreased cardiac APN receptor 2 (AdipoR2), reduced phosphorylation of Akt, signal transducer and activator of transcription 3 (STAT3) and endothelial nitric oxide synthase (eNOS) but increased IL-6 and TNF-? (all P<0.05 vs. |
| 12 | 21912612 | APN supplementation restored high glucose induced AdipoR2 reduction in cardiomyocytes. |
| 13 | 18025295 | Sera were assayed for angiotensin-converting enzyme activity, aminopeptidase P activity, aminopeptidase N activity, dipeptidyl peptidase IV activity, and antigen and the ex vivo degradation half-lives of bradykinin, des-Arg(9)-bradykinin, and substance P in a subset. |