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Gene Information
Gene symbol: APOC3
Gene name: apolipoprotein C-III
HGNC ID: 610
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | AKT1 | 1 hits |
| 2 | APOB | 1 hits |
| 3 | HNF1A | 1 hits |
| 4 | HNF4A | 1 hits |
| 5 | INS | 1 hits |
| 6 | JUN | 1 hits |
| 7 | LPAL2 | 1 hits |
| 8 | LPL | 1 hits |
| 9 | MAPK1 | 1 hits |
| 10 | NR1H3 | 1 hits |
| 11 | PIK3CA | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 11423471 | Quantitative evaluation of HNF-4alpha target gene expression revealed diminished mRNA levels for HNF-1alpha, GLUT2, L-type pyruvate kinase, aldolase B, apolipoprotein (apo)-B, and apoCIII. |
| 2 | 16223942 | The apolipoprotein C III (APOC3) promoter contains a HNF-4 but not HNF-1 binding site, and HNF-1alpha suppressed HNF-4alpha APOC3 activation and decreased HNF-4alpha promoter occupancy. |
| 3 | 16343038 | In the multiple stepwise linear regression analysis, apoB level seemed to be influenced by APOC3 SstI genotype, which explained 6 % of its variance. |
| 4 | 16343038 | The present study has shown that the S1 allele of APOC3 SstI polymorphism and the H- allele of LPL HindIII polymorphism might have a small effect on apoB levels in the Central European Caucasian population with dyslipidemia of metabolic syndrome. |
| 5 | 19196457 | It is suggested that elevated circulating apoCIII levels may contribute to beta-cell apoptosis via activation of p38 and ERK1/2 in individuals with T2DM. |
| 6 | 18835943 | To determine whether, in accordance with observations in mouse models, high concentrations of the lipoprotein lipase inhibitors apolipoprotein (Apo) CI and ApoCIII are associated with increased triglyceride concentrations and decreased fat mass in men with the metabolic syndrome. |
| 7 | 21183731 | ApoCIII induction by glucose is blunted by treatment with agonists of farnesoid X receptor and peroxisome proliferator-activated receptor-? but not liver X receptor, ie, nuclear receptors controlling triglyceride metabolism. |
| 8 | 21185820 | APOC3 -482TT genotype is associated with high apoC-III concentrations only in the presence of abdominal obesity or insulin resistance, but not in current smokers who remain lean or insulin-sensitive. |
| 9 | 20335584 | The polymorphisms C-482T and T-455C in APOC3 are associated with nonalcoholic fatty liver disease and insulin resistance. |
| 10 | 21670290 | The endogenous levels of apoCIII were reduced by treating prediabetic animals with an antisense against this apolipoprotein, resulting in a significantly delayed onset of diabetes. |
| 11 | 21693679 | ApoCIII had no effects on mitogen-activated protein kinases (c-Jun N-terminal kinase, p38, and ERK) and had no impact on IL-1?-induced c-Jun N-terminal kinase activation. |
| 12 | 21693679 | Further, ApoCIII caused degradation of the nuclear factor ?B-inhibitor inhibitor of ?B and stimulated Ser473-phosphorylation of the survival serine-threonine kinase Akt. |
| 13 | 21693679 | Inhibition of the Akt signaling pathway by the phosphatidylinositol 3 kinase inhibitor LY294002 counteracted the antiapoptotic effect of ApoCIII on cytokine-induced apoptosis. |
| 14 | 21693679 | We conclude that ApoCIII in the presence of T1D-relevant proinflammatory cytokines reduces rat pancreatic islet cell apoptosis via Akt. |