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Gene Information
Gene symbol: AURKA
Gene name: aurora kinase A
HGNC ID: 11393
Synonyms: BTAK, AurA, STK7, ARK1, PPP1R47, AIK
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CASP3 | 1 hits |
| 2 | EGF | 1 hits |
| 3 | INSR | 1 hits |
| 4 | SIRT2 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 3049675 | When normalized to insulin binding, insulin receptor autophosphorylation was normal in cells from Can-1, but reduced in those of Ark-1 and Minn-1. |
| 2 | 2569023 | To clarify the molecular basis of the insulin resistance, we investigated the insulin binding and kinase properties of the insulin receptor and the receptor gene in cultured skin fibroblasts of two patients (Ark-1 and Ark-2) with leprechaunism and in those of three of their parents. |
| 3 | 2808704 | Maximal epidermal growth factor (EGF) binding was reduced in fibroblasts from three unrelated patients with leprechaunism (Ark-1, Can-1, and Minn-1) compared with control (0.8-2.2%/mg protein vs. 5.5%/mg protein). |
| 4 | 19370169 | In addition, nine isolates inhibited aurora kinase A, an anti-cancer related protein, and three inhibited caspase 3, a protein related to neurodegenerative diseases. |
| 5 | 22014574 | SIRT2 deficiency caused increased levels of mitotic regulators, including Aurora-A and -B that direct centrosome amplification, aneuploidy, and mitotic cell death. |