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Gene Information

Gene symbol: BCL2L11

Gene name: BCL2-like 11 (apoptosis facilitator)

HGNC ID: 994

Synonyms: BOD, BimL, BimEL, BimS, BIM

Related Genes

#	Gene Symbol	Number of hits
1	AKT1	1 hits
2	BAD	1 hits
3	MAPK8	1 hits
4	MCL1	1 hits
5	PTPN2	1 hits
6	SPHK1	1 hits
7	STAT1	1 hits

Related Sentences

#	PMID	Sentence
1	21354306	IRS overexpression increased MnSOD abundance as well as BAD phosphorylation while Bim and BAX levels remained unchanged.
2	21625639	Further mechanistic study examined the expression of Bcl-2 family members, including Bcl-2, Mcl-1, Bax and Bim, in SPHK1-overexpressing glioma cells and revealed that only pro-apoptotic Bim was downregulated by SPHK1.
3	21625639	Moreover, the transcriptional level of Bim was also altered by SPHK1 in glioma cells.
4	17667983	Exposure to AGE-BSA was associated with Akt dephosphorylation and FOXO4 transcriptional activation leading to an increase in the expression of an effector protein of apoptosis, Bim. siRNA for FOXO4 abolished AGE-BSA-induced apoptosis of podocytes.
5	21977009	Indeed, Bim knockdown prevented both dsRNA- and Coxsackievirus B5-induced beta cell death, and counteracted the proapoptotic effects of Mcl-1 silencing.
6	21937453	Bim expression was transcriptionally regulated by STAT1, and its activation triggered cleavage of caspases.
7	21984578	RESEARCH DESIGN AND METHODS Small interfering RNAs were used to inhibit PTPN2, STAT1, Bim, and Jun NH(2)-terminal kinase 1 (JNK1) expression.
8	21984578	There was also an increase in Bim phosphorylation that was at least in part regulated by JNK1.
9	21984578	CONCLUSIONS The present findings suggest that local IFN production may interact with a genetic factor (PTPN2) to induce aberrant proapoptotic activity of the BH3-only protein Bim, resulting in increased ?-cell apoptosis via JNK activation and the intrinsic apoptotic pathway.