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Gene Information
Gene symbol: CDKAL1
Gene name: CDK5 regulatory subunit associated protein 1-like 1
HGNC ID: 21050
Synonyms: FLJ20342
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | AAAS | 1 hits |
| 2 | CD19 | 1 hits |
| 3 | CD4 | 1 hits |
| 4 | CDK5 | 1 hits |
| 5 | FTO | 1 hits |
| 6 | INS | 1 hits |
| 7 | MPG | 1 hits |
| 8 | PEPD | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 18285412 | Our objective was to investigate the impact of rs7754840 of CDKAL1 on insulin secretion, insulin sensitivity, and risk of type 2 diabetes. |
| 2 | 18285412 | In study 2, rs7754840 was significantly associated with type 2 diabetes (P = 0.022) and markers of impaired insulin release [insulinogenic index (IGI), P = 0.012] in 2405 men with normal glucose tolerance. rs7754840 of CDKAL1 was associated with markers of impaired insulin secretion in two independent studies. |
| 3 | 18285412 | Therefore, CDKAL1 is likely to increase the risk of type 2 diabetes by impairing insulin secretion. |
| 4 | 19258404 | In our cohort, only polymorphisms in SLC30A8, HHEX, TCF7L2, and CDKAL1 influenced insulin secretion. |
| 5 | 19401414 | Four loci-1 novel with suggestive evidence (PEPD on 19q13, P = 1.4 x 10(-5)) and three previously reported-were identified; the association of CDKAL1, CDKN2A/CDKN2B, and KCNQ1 were confirmed (P < 10(-19)). |
| 6 | 19622614 | The fetal insulin hypothesis proposes that common genetic variants that reduce insulin secretion also reduce birth weight, and an association of low birth weight and the type 2 diabetes risk alleles at the HHEX-IDE and CDKAL1 loci were recently reported. |
| 7 | 19587699 | Finally, we report the results of expression studies demonstrating that CDKAL1 transcripts are virtually absent from skin keratinocytes, but are abundantly expressed in immune cells, especially in CD4+ and CD19+ lymphocytes. |
| 8 | 20509872 | Moreover, the relationship between FTO-rs8050136 and body mass index, together with the effect of CDKAL1-rs10946398 on beta cell function, was also observed in the control individuals. |
| 9 | 21151568 | A variant of the CDKAL1 gene was reported to be associated with type 2 diabetes and reduced insulin release in humans; however, the role of CDKAL1 in ? cells is largely unknown. |
| 10 | 21151568 | Our results indicate that CDKAL1 controls first-phase insulin exocytosis in ? cells by facilitating ATP generation, K(ATP) channel responsiveness and the subsequent activity of Ca(2+) channels through pathways other than CDK5-mediated regulation. |
| 11 | 21841312 | Here, we show that Cdkal1 is a mammalian methylthiotransferase that biosynthesizes 2-methylthio-N6-threonylcarbamoyladenosine (ms2t6A) in tRNA(Lys)(UUU) and that it is required for the accurate translation of AAA and AAG codons. |
| 12 | 21841312 | Mice with pancreatic ? cell-specific KO of Cdkal1 (referred to herein as ? cell KO mice) showed pancreatic islet hypertrophy, a decrease in insulin secretion, and impaired blood glucose control. |