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Gene Information
Gene symbol: CDKN2B
Gene name: cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
HGNC ID: 1788
Synonyms: P15, MTS2, INK4B, TP15, CDK4I, p15INK4b
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | IFNG | 1 hits |
| 2 | IGF2BP2 | 1 hits |
| 3 | MEN1 | 1 hits |
| 4 | SLC30A8 | 1 hits |
| 5 | STAT5A | 1 hits |
| 6 | TP53 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 19141585 | Rare germline mutation in any among four (p15, p18, p21, and p27) of the seven CDKIs is a probable cause of MEN1 or of some related states. |
| 2 | 20716961 | The INK4b-ARF-INK4a locus encodes for two cyclin-dependent kinase inhibitors, p15(INK4b) and p16(INK4a) and a regulator of the p53 pathway, ARF. |
| 3 | 17463246 | With collaborators (FUSION and WTCCC/UKT2D), we identified and confirmed three loci associated with T2D-in a noncoding region near CDKN2A and CDKN2B, in an intron of IGF2BP2, and an intron of CDKAL1-and replicated associations near HHEX and in SLC30A8 found by a recent whole-genome association study. |
| 4 | 21038417 | We further demonstrate that growth hormone, through the transcription factor STAT5, enhances expression of the Cdkn2b (cyclin-dependent kinase inhibitor 2B) gene and that STAT5A binds to interferon-gamma-activated sequence sites within the promoter. |
| 5 | 21038417 | Loss of STAT5 led to diminished p15(INK4B) and increased hepatocyte proliferation. |