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Gene Information
Gene symbol: CSF2
Gene name: colony stimulating factor 2 (granulocyte-macrophage)
HGNC ID: 2434
Synonyms: GM-CSF, GMCSF
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | ATN1 | 1 hits |
| 2 | CRTAM | 1 hits |
| 3 | CSF1 | 1 hits |
| 4 | ICAM1 | 1 hits |
| 5 | IL6 | 1 hits |
| 6 | IRF4 | 1 hits |
| 7 | STAT5A | 1 hits |
| 8 | TGFB1 | 1 hits |
| 9 | TNF | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 11120352 | They produce antithrombotic and thrombotic factors such as t-PA and PAI-1 and respond to TNFalpha, an important factor correlated with the inflammatory process by modifying growth characteristics by producing cytokines such as GM-CSF by expressing ICAM-1 on the surface and by producing large amounts of nitric oxide and endothelin. |
| 2 | 19165346 | In the absence of M-CSF signaling, NOD myeloid cells have abnormally high granulocyte macrophage colony-stimulating factor (GM-CSF) expression, and as a result, persistent activation of signal transducer/activator of transcription 5 (STAT5). |
| 3 | 19165346 | Moreover, if M-CSF signaling is inhibited, GM-CSF stimulation in vitro can promote STAT5 phosphorylation in nonautoimmune C57BL/6 mouse bone marrow cultures to levels seen in the NOD. |
| 4 | 19165346 | These findings suggest that excessive GM-CSF production in the NOD bone marrow may interfere with the temporal sequence of GM-CSF and M-CSF signaling needed to mediate normal STAT5 function in myeloid cell differentiation gene regulation. |
| 5 | 20061825 | MAb E4 potently antagonized the cytolytic activity of NKL cells against BaF/3-MICA cells expressing NKG2D ligand, and blocked the NKG2D ligand-induced secretion of TNFalpha, IFNgamma and GM-CSF, as well as surface expression of CRTAM by NK cells cultured on immobilized MICA or ULBP-1 ligands. |
| 6 | 19799605 | Exogenous GM-CSF substantially enhanced the wound healing in diabetic mice, accompanied by increased interleukin-6 and monocyte chemoattractant protein-1 production. |
| 7 | 20544263 | Monocyte-derived dendritic cells (DCs) were produced utilizing GM-CSF and IL-4, and aaDCs by adding IL-10 and TGF-beta (10/TGF-DC) during differentiation. |
| 8 | 21647406 | Importantly, levels of IRF4 and IRF8 expression were lower in tolerogenic bone marrow derived DCs (BMDCs) generated with GM-CSF as compared to immunogenic BMDCs generated with GM-CSF and IL-4. |
| 9 | 18945591 | This overproduction prolongs the activation of signal transduction and activator of transcription 5 (STAT5) proteins, involved in GM-CSF-induced control of myeloid cell gene expression. |
| 10 | 18945591 | We found that GM-CSF can regulate the binding of STAT5 on the promoter of its own gene, Csf2, within regions previously identified as sites of chromatin epigenetic modification important to the regulation of GM-CSF during myeloid differentiation and inflammation. |
| 11 | 18945591 | Thus, GM-CSF overproduction by NOD myeloid cells may be perpetuating a positive epigenetic regulatory feedback on its own gene expression through its induction of STAT5 binding to its promoter. |