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Gene Information
Gene symbol: CYP1A1
Gene name: cytochrome P450, family 1, subfamily A, polypeptide 1
HGNC ID: 2595
Synonyms: P450DX, P1-450, P450-C, CP11
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | AHR | 1 hits |
| 2 | ARNT | 1 hits |
| 3 | CNBP | 1 hits |
| 4 | CYP17A1 | 1 hits |
| 5 | CYP2B6 | 1 hits |
| 6 | CYP2C19 | 1 hits |
| 7 | CYP2D6 | 1 hits |
| 8 | CYP2E1 | 1 hits |
| 9 | CYP3A4 | 1 hits |
| 10 | EPHX2 | 1 hits |
| 11 | INS | 1 hits |
| 12 | POR | 1 hits |
| 13 | TBXAS1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 21929725 | Since hepatic CYP2E1 expression is increased in different physiopathological situations such as type 2 diabetes, obesity and ethanol intoxication, the presence of significant levels of this CYP within the mitochondria could have major deleterious effects. |
| 2 | 153061 | Insulin treatment of diabetic animals returned the altered AHH activity to control values in both sexes of rats. 2. |
| 3 | 6365718 | P-450 content decreased with increasing severity of liver histological changes, whereas AHH and ECD activities were significantly reduced only in biopsies with severe histological changes. |
| 4 | 11809858 | AhR is a cytosolic ligand-dependent transcription factor that, in conjunction with the AhR nuclear translocator (Arnt), binds to dioxin response elements (DREs) located in the promoter region of target genes, such as CYP1A1, and induces their transcription. |
| 5 | 15069169 | Amiodarone is a potent inhibitor of several different CYP isoenzymes, including CYP3A4. |
| 6 | 15242186 | In this paper, we present the effects of two organic fractions and two aqueous extracts from the leaves of S. sonchifolius on rat hepatocyte viability, on oxidative damage induced by tert-butyl hydroperoxide (t-BH) and allyl alcohol (AA), and on glucose metabolism and their insulin-like effect on the expression of cytochrome P450 (CYP) mRNA. |
| 7 | 19903449 | With the BROD assay, we could clearly dissect CYP3A11 from other P450s induced by phenytoin-like CYP2C29, CYP2B9, CYP1A1, and CYP4A. |
| 8 | 20878594 | Evidence of cytochrome P450 (CYP)2D6 inhibition in clinical trials highlighted a concern for pharmacokinetic interaction with other drugs that are CYP2D6 substrates, as confirmed by a rise in the pharmacokinetic parameters of desipramine with concomitant administration of mirabegron. |
| 9 | 20410220 | Like all other microsomal cytochrome P450 (CYP) enzymes, CYP17A1 requires electron transfer from P450 oxidoreductase (POR). |
| 10 | 21757024 | A recent publication has demonstrated that stabilizing the levels of epoxyeicosatrienoic acids (EETs), CYP eicosanoids, by inhibiting or deleting soluble epoxide hydrolase (sEH) improves ?-cell function and reduces ?-cell apoptosis in diabetes. |
| 11 | 21568932 | Patients with DM2 show an improvement of plasma lipoprotein profile and glucose tolerance together with increase in liver phospholipid (PL) and cytochrome (CYP) P450. |
| 12 | 20437462 | GLB depletion and metabolite formation in human liver microsomes were most significantly inhibited by the CYP3A inhibitor ketoconazole compared with the inhibitors of other CYP isoforms. |
| 13 | 21787170 | CYP2D6 was the primary recombinant human CYP producing these metabolites, followed by CYP1A2, 3A4, 2E1 and CYP2C19. |