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Gene Information
Gene symbol: EDNRA
Gene name: endothelin receptor type A
HGNC ID: 3179
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | EDN1 | 1 hits |
| 2 | EDNRB | 1 hits |
| 3 | INS | 1 hits |
| 4 | VEGFA | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 8365355 | This increase in receptor density probably resulted from the stimulation of receptor protein production, because insulin caused a maximal 2.3 +/- 0.3 (+/- SEM) fold increase in the ETA receptor mRNA expressed in cultured VSMC by 4 h. |
| 2 | 9533832 | Cross-linking of [125I]ET-1 and [125I]ET-3 to ciliary body membranes resulted in the labeling of two bands with apparent molecular masses of 52 and 34 kDa, suggesting that ETA and ETB receptors have similar molecular mass. |
| 3 | 11127715 | Furthermore, effects of a mixed ETA and ETB receptor antagonist, bosentan, were studied. |
| 4 | 11139780 | The gene expression of ETA and ETB receptors ET-1, ET-3 and ECE-1 was evaluated using relative multiplex reverse transcription/PCR. |
| 5 | 12663685 | Selective ET-1 receptor antagonists showed in the control group that the ETB subtype inhibits ETA regulation of Ca2+m. |
| 6 | 15838254 | Furthermore, ETA receptor blockade is effective in increasing ETB receptor gene expression, suggesting a potential role for endothelin ETA antagonists in the treatment of type 1 diabetes. |
| 7 | 16080914 | The retina from the diabetic rats showed increased ET-1 mRNA expression after 2 weeks, while no changes were found for ET-3, ET-A and ET-B. |
| 8 | 16906650 | Here, we report that down-regulated VEGF expression in the diabetic rat heart is normalized by an endothelin ETA receptor antagonist, suggesting that endothelin antagonism may be a novel therapeutic strategy for diabetic heart. |
| 9 | 20727565 | We compared the contractile responses to endothelin-1 (ET-1) with and without the inhibition of ET-A receptors and protein kinase C-alpha (PKC-?) in the human peripheral microvasculature of diabetic and case-matched, nondiabetic patients. |
| 10 | 20727565 | Microvascular constriction was assessed by videomicroscopy in response to ET-1 with and without an endothelin-A (ET-A) receptor antagonist, an endothelin B (ET-B) antagonist, or a PKC-? inhibitor. |
| 11 | 20727565 | The contractile response of diabetic vessels to ET-1 occurs via activation of ET-A receptors and PKC-?. |