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Gene Information
Gene symbol: EIF2AK2
Gene name: eukaryotic translation initiation factor 2-alpha kinase 2
HGNC ID: 9437
Synonyms: PKR, EIF2AK1
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | ATF6 | 1 hits |
| 2 | CYBA | 1 hits |
| 3 | EIF2AK3 | 1 hits |
| 4 | EIF2S1 | 1 hits |
| 5 | IFNA1 | 1 hits |
| 6 | IFNG | 1 hits |
| 7 | INS | 1 hits |
| 8 | INSR | 1 hits |
| 9 | LEP | 1 hits |
| 10 | MAPK8 | 1 hits |
| 11 | NCF1 | 1 hits |
| 12 | NCF2 | 1 hits |
| 13 | NFKB1 | 1 hits |
| 14 | NOS2A | 1 hits |
| 15 | POMC | 1 hits |
| 16 | PRKRA | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 10026192 | In contrast to PKR or HRI, which are dependent on autophosphorylation for their kinase activity, a point mutation that replaced the conserved Lys-614 with an alanine completely abolished the eIF-2alpha kinase activity, whereas the mutant PEK was still autophosphorylated when expressed in Sf-9 cells. |
| 2 | 11694524 | Interferon regulatory factor-1 (IRF-1), the activation of which is induced by dsRNA, viral infection, and IFN-gamma, regulates the expression of many antiviral proteins, including PKR, type I IFN, and iNOS. |
| 3 | 20144759 | Here, we provide evidence that double-stranded RNA-dependent protein kinase (PKR) can respond to nutrient signals as well as endoplasmic reticulum (ER) stress and coordinate the activity of other critical inflammatory kinases such as the c-Jun N-terminal kinase (JNK) to regulate insulin action and metabolism. |
| 4 | 20144759 | PKR also directly targets and modifies insulin receptor substrate and hence integrates nutrients and insulin action with a defined pathogen response system. |
| 5 | 21267711 | With a single injection of streptozotocin 65 mg/kg, ip in rats, early diabetic nephropathy was produced and revealed as an increased microalbuminuria, elevated creatinine and urea in serum, associated with upregulation of mRNA and protein of NADPH oxidase p22phox, p47phox, and p67phox and ET(A), upregulated PKR-like eukaryotic initiation factor 2? kinase (PERK), and downregulated Cx43 in the renal tissue. |
| 6 | 21345978 | The three major arms of the mammalian UPR include 1) protein kinase RNA (PKR)-like ER kinase (PERK), 2) inositol-requiring protein-1 (IRE1?), and 3) activating transcription factor-6 (ATF6) pathways. |
| 7 | 15661870 | The 2-5AS/RNase L pathway was critical for IFN-alpha-mediated islet cell resistance from CV serotype B4 (CVB4) infection and replication, whereas an intact PKR pathway was required for efficient IFN-gamma-mediated repression of CVB4 infection and replication. |
| 8 | 21897745 | Our results suggest that RAX expression may be indirectly regulated by miR-29b, and the upregulation of this miRNA at the early stage of STZ-induced diabetes may have a protective effect against the apoptosis of RGCs and cells of the INL by the pro-apoptotic RNA-dependent protein kinase (PKR) signaling pathway. |
| 9 | 11272138 | This study examines the role of nuclear factor-kappaB (NF-kappaB) and the dsRNA-dependent protein kinase (PKR) in dsRNA + IFN-gamma-induced nitric oxide synthase (iNOS) expression and nitric oxide production by rat, mouse, and human islets. |
| 10 | 11272138 | PKR has been shown to participate in dsRNA-induced NF-kappaB activation in a number of cell types, including mouse embryonic fibroblasts. |
| 11 | 11272138 | Furthermore, the genetic absence of PKR did not affect dsRNA + IFN-gamma-induced iNOS expression, nitric oxide production, or the inhibitory actions of these agents on glucose-stimulated insulin secretion. |
| 12 | 11272138 | These results suggest that 1) NF-KB activation is required for dsRNA + IFN-gamma-induced iNOS expression, 2) PKR is not required for either dsRNA-induced NF-kappaB activation or dsRNA + IFN-y-induced iNOS expression by islets, and 3) PKR is not required for dsRNA + IFN-gamma-induced inhibition of glucose-stimulated insulin secretion by islets. |
| 13 | 21873226 | These effects coincided with activation of leptin and insulin signaling pathways and down-regulation of the PKR-like endoplasmic reticulum (ER) kinase/eukaryotic translation inhibition factor 2? (PERK-eIF2?) arm of ER stress in liver, skeletal muscle, and adipose tissue as well as increased pro-opiomelanocortin and decreased agouti-related peptide in the hypothalamus. |