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Gene Information
Gene symbol: GADD45A
Gene name: growth arrest and DNA-damage-inducible, alpha
HGNC ID: 4095
Synonyms: GADD45
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | DDIT3 | 1 hits |
| 2 | GADD45B | 1 hits |
| 3 | GADD45G | 1 hits |
| 4 | JUN | 1 hits |
| 5 | MAPK1 | 1 hits |
| 6 | POU2F1 | 1 hits |
| 7 | PPARG | 1 hits |
| 8 | TRO | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 12881480 | Using adenoviral-mediated overexpression of a constitutively active PPARgamma mutant and the irreversible PPARgamma antagonist GW9662, we provide evidence that PPARgamma ligands induce caspase-mediated apoptosis and GADD45 expression through a receptor-dependent pathway. |
| 2 | 12881480 | Deletion analysis of the GADD45 promoter revealed that a 153-bp region between -234 and -81 bp proximal to the transcription start site, containing an Oct-1 element, was crucial for the PPARgamma ligand-mediated induction of the GADD45 promoter. |
| 3 | 12881480 | These findings suggest that activation of PPARgamma can lead to apoptosis and growth arrest in VSMCs, at least in part, by inducing Oct-1-mediated transcription of GADD45. |
| 4 | 15064713 | TRO induced GADD45 mRNA expression in a time- and dose-dependent manner. |
| 5 | 15064713 | Several mitogen-activated protein kinase (MAPK) pathways were involved in the induction of GADD45 by TRO. |
| 6 | 15064713 | Inhibition of the c-jun N-terminal kinase MAPK pathway by SP600125 partially abolished TRO-induced GADD45 mRNA, and protein expression and apoptosis. |
| 7 | 15064713 | In contrast, inhibition of the p38 MAPK pathway by SB203580, or through overexpression of a dominant-negative mutant of p38 MAPK, augmented GADD45 mRNA induction and GADD45 promoter activation as well as cell apoptosis by TRO. |
| 8 | 16283526 | In addition to gadd45alpha, the basal expression of other gadd family members including gadd45beta, gadd45gamma and gadd153 was substantially increased in Ikkbeta-/- cells. |
| 9 | 16283526 | Ikkbeta deficiency prevented the induction of gadd45beta and gadd45gamma by arsenic, whereas the induction of gadd45alpha and gadd153 was appreciably enhanced in Ikkbeta-/- cells. |