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Gene Information
Gene symbol: HTR1B
Gene name: 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled
HGNC ID: 5287
Synonyms: S12, 5-HT1B, HTR1D2, 5-HT1DB
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CARTPT | 1 hits |
| 2 | GHRL | 1 hits |
| 3 | HCRT | 1 hits |
| 4 | HTR2C | 1 hits |
| 5 | POMC | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 16973729 | Here, we report that 5-wk-old Ay mice consumed more food in association with decreases in levels of plasma des-acyl ghrelin, but not active ghrelin, and increases in hypothalamic 5-HT2C and 5-HT1B receptor gene expression compared with wild-type mice matched for age and body weight. |
| 2 | 17218444 | Neither SB242084, a selective 5-HT2C receptor antagonist, nor SB224289, a selective 5-HT1B receptor antagonist, reversed the appetite-suppressing effects of milnacipran. |
| 3 | 17218444 | These results suggest that inhibition of 5-HT and NA reuptake induces appetite-suppressing effects independent of 5-HT2C and 5-HT1B receptors, and increases hypothalamic POMC and CART gene expression without increasing plasma corticosterone and blood glucose levels in mice. |
| 4 | 16959056 | Moreover, CP 94253 (5-10 mg/kg), a selective 5-HT1B receptor agonist, exerted appetite-suppressing effects and significantly increased hypothalamic pro-opiomelanocortin (POMC) and cocaine- and amphetamine-regulated transcript (CART) gene expression and decreased hypothalamic orexin gene expression. |
| 5 | 16959056 | These results suggest that fluvoxamine and inactivation of 5-HT2C receptors exert feeding suppression through activation of 5-HT1B receptors, and that 5-HT1B receptors up-regulate hypothalamic POMC and CART gene expression and down-regulate hypothalamic orexin gene expression in mice. |
| 6 | 18976545 | We previously reported that fluvoxamine, a selective serotonin reuptake inhibitor, together with pharmacological inactivation of 5-HT2C receptors exert feeding suppression through activation of 5-HT1B receptors in mice. |