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Gene Information
Gene symbol: IL21
Gene name: interleukin 21
HGNC ID: 6005
Synonyms: Za11, IL-21
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CCR9 | 1 hits |
| 2 | CXCR5 | 1 hits |
| 3 | FOXP3 | 1 hits |
| 4 | IL21R | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 21511186 | CCR9+ Th cells expressed large amounts of IL-21, inducible T cell costimulator (ICOS), and the transcription factors Bcl6 and Maf, and also supported antibody production from B cells, thereby resembling T follicular B helper (Tfh) cells. |
| 2 | 21511186 | However, in contrast to Tfh cells, CCR9+ Th cells displayed limited expression of CXCR5 and the targets of CCR9+ Th cells were CD8+ T cells whose responsiveness to IL-21 was necessary for the development of diabetes. |
| 3 | 22013017 | RESEARCH DESIGN AND METHODS The interplay between IL-21/IL-21R signaling, FoxP3 expression, and Treg survival and function was evaluated in vitro in immunologically relevant assays and in vivo in allogenic and autoimmune models of islet transplantation. |
| 4 | 22013017 | RESULTS IL-21R expression decreases on T cells and B cells in vitro and increases in the graft in vivo, while IL-21 levels increase in vitro and in vivo during anti-CD3/anti-CD28 stimulation/allostimulation in the late phase of the alloimmune response. |
| 5 | 22013017 | In vitro, IL-21/IL-21R signaling (by using rmIL-21 or genetically modified CD4(+) T cells [IL-21 pOrf plasmid-treated or hIL-21-Tg mice]) enhances the T-cell response during anti-CD3/anti-CD28 stimulation/allostimulation, prevents Treg generation, inhibits Treg function, induces Treg apoptosis, and reduces FoxP3 and FoxP3-dependent gene transcripts without affecting FoxP3 methylation status. |