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Gene Information
Gene symbol: ISL1
Gene name: ISL LIM homeobox 1
HGNC ID: 6132
Synonyms: Isl-1, ISLET1
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | ABCC8 | 1 hits |
| 2 | FOXA1 | 1 hits |
| 3 | HNF4A | 1 hits |
| 4 | INS | 1 hits |
| 5 | KCNJ11 | 1 hits |
| 6 | KLRG1 | 1 hits |
| 7 | LDB1 | 1 hits |
| 8 | MYC | 1 hits |
| 9 | NEUROG3 | 1 hits |
| 10 | POU3F4 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 21814221 | Variants in USF1, ABCC8, ISL1 and KCNJ11 showed nominal association, while haplotypes in these genes were significantly associated. rs3812704 upstream of NEUROG3 significantly increased risk for type 2 diabetes in normal-weight/lean subjects (OR=1.68 (95%CI 1.25-2.24), P=4.9 × 10(-4)). |
| 2 | 8425669 | IAPP at 10(-7) M reduced insulin release by 32% from 7.1 (95% Cl 5.8-8.6) to 4.8 (3.0-7.5) fmol.min-1 x islet-1 (P = 0.046, n = 7). |
| 3 | 8425669 | IAPP at 1.5 x 10(-6) M reduced insulin release by 62% from 6.5 (3.4-12.3) to 2.5 (1.4-4.4) fmol.min-1 x islet-1 (P = 0.001, n = 6). |
| 4 | 7912209 | The islet-1 (Isl-1) gene encodes a protein that binds to the enhancer region of the insulin gene. |
| 5 | 7789634 | Islet-1 (Isl-1) is a unique transcription factor that binds to the enhancer region of the insulin gene. |
| 6 | 11978636 | In fact, overexpression of both Pdx-1 and Isl-1 in IEC-6 cells (Isl-YK-12, -14, and -15 cells) gave them the ability to express insulin without exposure to betacellulin. |
| 7 | 16873704 | We examined the association of variants in genes encoding several transcription factors (TCF1, TCF2, HNF4A, ISL1, IPF1, NEUROG3, PAX6, NKX2-2, NKX6-1, and NEUROD1) and genes encoding the ATP-sensitive K(+) channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) with type 2 diabetes in a Japanese cohort of 2,834 subjects. |
| 8 | 17022998 | Here, we showed that Isl1 could enhance the HNF4alpha-mediated activation of transcription of the HNF1alpha, PPARalpha and insulin I promoters. |
| 9 | 17022998 | Isl1 interacted with the HNF4alpha AF-2 but also required the HNF4alpha carboxy-terminal F domain for optimal interaction and transcriptional synergy. |
| 10 | 17022998 | Moreover, Isl1 could mediate the recruitment of the cofactor CLIM2 resulting in a further transcriptional enhancement of the HNF1alpha promoter activity. |
| 11 | 19737569 | The mRNA levels of transcription factors Islet-1 and Pax6 were reduced significantly in the small intestine, showing that Foxa1 and Foxa2 impact on a transcription factor network in the enteroendocrine lineage. |
| 12 | 21099304 | We have also identified MafA, a potent Insulin gene regulator, as the first direct target of Isl-1 in ?-cells. |
| 13 | 19502415 | In addition, MafA, a potent regulator of the Insulin gene and beta-cell function, was identified as a direct transcriptional target of Isl-1. |
| 14 | 10677506 | Recent genetic studies have identified a network of transcription factors, including Pdx1, Isl1, Pax4, Pax6, NeuroD, Nkx2.2, and Hlxb9, regulating the development of islet cells at different stages, but the molecular mechanisms controlling the specification of pancreatic endocrine precursors remain unknown. neurogenin3 (ngn3) is a member of a family of basic helix-loop-helix transcription factors that is involved in the determination of neural precursor cells in the neuroectoderm. ngn3 is expressed in discrete regions of the nervous system and in scattered cells in the embryonic pancreas. |
| 15 | 10868931 | The earliest sign of alpha-cell development appears to be Brain4 expression, which apparently precedes Islet-1 (ISL1) expression. |
| 16 | 15561947 | We do not however find any expression of the late-stage genes (Pax4, Pax6, Isl-1, and MafA) related to beta-cell development, and the cells do not secrete insulin upon the glucose challenge. |
| 17 | 21829621 | Using HIT-T15 and primary adult islet cells as cell models, we show that ISL1 promoted adult pancreatic islet cell proliferation with increased c-Myc and CyclinD1 transcription, while knockdown of ISL1 increased the proportion of cells in G(1) phase and decreased the proportion of cells in G(2)/M and S phases. |
| 18 | 21829621 | Further investigation shows that ISL1 activated both c-Myc and CyclinD1 transcription through direct binding on their promoters. |