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Gene Information
Gene symbol: ITGAX
Gene name: integrin, alpha X (complement component 3 receptor 4 subunit)
HGNC ID: 6152
Synonyms: CD11c
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | ADAM8 | 1 hits |
| 2 | CD163 | 1 hits |
| 3 | CLEC7A | 1 hits |
| 4 | EBI3 | 1 hits |
| 5 | IL1B | 1 hits |
| 6 | IL1R1 | 1 hits |
| 7 | IL27RA | 1 hits |
| 8 | IL2RA | 1 hits |
| 9 | INS | 1 hits |
| 10 | ITGAM | 1 hits |
| 11 | LYVE1 | 1 hits |
| 12 | MMP12 | 1 hits |
| 13 | PPARA | 1 hits |
| 14 | PPARGC1A | 1 hits |
| 15 | SPHK1 | 1 hits |
| 16 | VEGFA | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 21925473 | The infiltration of islets by F4/80(+)CD11c(-)7/4(-) macrophages, CD4(+) T cells, and CD8(+) T cells was increased in EBI3(-/-) and WSX-1(-/-) mice compared with WT mice. |
| 2 | 16807303 | We also found two populations of F4/80+, CD11b+, ICAM-1+ cells, one of which also expressed CD14 and CD11c and was increased in response to a high-fat diet. |
| 3 | 17785799 | Depletion of CD11c+ DCs before transfer released diabetogenic T cells from the suppressive effect of CD4+CD25+ Tregs, thereby promoting the development of diabetes. |
| 4 | 20357360 | In obese women, CD11c(+) ATM density was greater in subcutaneous than omental adipose tissue and correlated with markers of insulin resistance. |
| 5 | 20185806 | CD11c(+) eATMPhis expressed a mixed M1/M2 profile, with some M1 transcripts upregulated (IL-12p40 and IL-1beta), others downregulated (iNOS, caspase-1, MCP-1, and CD86), and multiple M2 and matrix remodeling transcripts upregulated (arginase-1, IL-1Ra, MMP-12, ADAM8, VEGF, and Clec-7a). |
| 6 | 20185806 | MGL1(med)/CD11c(+) eATMPhis upregulated additional M2 genes (IL-13, SPHK1, CD163, LYVE-1, and PPAR-alpha). |
| 7 | 20185806 | MGL1(med)/CD11c(+) ATMPhis expressing elevated PGC-1alpha, PPAR-alpha, and Ym-1 transcripts were selectively enriched in eAT of obese mice fed pioglitazone for 6 days, confirming the M2 features of the MGL1(med)/CD11c(+) eATMPhi transcriptional profile and implicating PPAR activation in its elicitation. |