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Gene Information
Gene symbol: KLF11
Gene name: Kruppel-like factor 11
HGNC ID: 11811
Synonyms: Tieg3, MODY7
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CAT | 1 hits |
| 2 | EP300 | 1 hits |
| 3 | INS | 1 hits |
| 4 | PDX1 | 1 hits |
| 5 | SLC25A18 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 19122346 | Furthermore, it has been reported that over-expression of KLF11 has a deleterious effect on insulin promoter activity. |
| 2 | 19843526 | Here, we show that KLF11, an SP/Krüppel-like (SP/KLF) transcription factor, mutated in French maturity onset diabetes of the young patients (MODY7), regulates Pdx-1 transcription in beta cells through two evolutionarily conserved GC-rich motifs in conserved Area II, a control region essential to islet beta cell-enriched expression. |
| 3 | 19843526 | KLF11 specifically associates with Area II in chromatin immunoprecipitation assays, while preventing binding to GC1- and/or GC2-compromised Pdx1-driven reporter activity in beta cell lines. |
| 4 | 19843526 | Mechanistically, we find that KLF11 interacts with the coactivator p300 via its zinc finger domain in vivo to mediate Pdx-1 activation. |
| 5 | 15774581 | Here, we report, for the first time, to our knowledge, the characterization of KLF11 as a glucose-inducible regulator of the insulin gene. |
| 6 | 15774581 | A combination of random oligonucleotide binding, EMSA, luciferase reporter, and chromatin immunoprecipitation assays shows that KLF11 binds to the insulin promoter and regulates its activity in beta cells. |
| 7 | 15774581 | Interestingly, all three nonsynonymous KLF11 variants show increased repression of the catalase 1 promoter, suggesting a role in free radical clearance that may render beta cells more sensitive to oxidative stress. |