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Gene Information
Gene symbol: KLK3
Gene name: kallikrein-related peptidase 3
HGNC ID: 6364
Synonyms: PSA
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | GAD1 | 1 hits |
| 2 | HLA-DRB1 | 1 hits |
| 3 | INS | 1 hits |
| 4 | INSR | 1 hits |
| 5 | JAK2 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 7505244 | All sera immunoprecipitated GAD from [35S]methionine-labeled rat islet lysates and the sera from patients with SMS and APS I, but none of the IDDM patients' sera, identified the GAD protein in Western blots. |
| 2 | 15378031 | A newly developed bridging yeast tri-hybrid assay showed that APS dimerizes JAK2, insulin receptor and IGF1 receptor kinases using its SH2 and dimerization domains. |
| 3 | 15767667 | At lower levels of SH2-B or APS expression, dimerization approximates two JAK2 molecules to induce transactivation. |
| 4 | 15767667 | SH2-B or APS homodimerization and SH2-B/APS heterodimerization thus provide direct mechanisms for activating and inhibiting JAK2 and other kinases from the inside of the cell and for potentiating or attenuating cytokine and growth factor receptor signaling when ligands are present. |
| 5 | 19383895 | PSA values were significantly reduced in men with insulin treatment (-39%; P = 0.006) and oral diabetic medication (-24%; P = 0.030), and in men with elevated (6.1-6.9%) and highly (> or =7%) elevated hemoglobin A1c values (-15%, P = 0.004 and -29%, P = 0.003, respectively). |
| 6 | 21388354 | In this controlled study, 98 patients with APS type 2, 96 patients with type 1 diabetes (T1D), and 92 patients with autoimmune thyroid disease, both as a single autoimmune endocrinopathy, were tested for association with alleles of the human leukocyte antigen (HLA) class II loci DRB1, DQA1, and DQB1. |