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Gene Information
Gene symbol: LPIN1
Gene name: lipin 1
HGNC ID: 13345
Synonyms: KIAA0188
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | ADIPOQ | 1 hits |
| 2 | INS | 1 hits |
| 3 | NRIP1 | 1 hits |
| 4 | REG3A | 1 hits |
| 5 | RP9 | 1 hits |
| 6 | SAT1 | 1 hits |
| 7 | SIRT1 | 1 hits |
| 8 | TNF | 1 hits |
| 9 | TNFRSF1A | 1 hits |
| 10 | TNFRSF1B | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 17003347 | Lipin-alpha and -beta are the alternatively spliced gene products of the Lpin1 gene, whose product lipin is required for adipocyte differentiation. |
| 2 | 17950103 | Real-time polymerase chain reaction was used to measure gene expression of LPIN1 and adipogenic (PPARgamma, SREBP1c) and inflammatory markers (IL6, TNFalpha, TNFR1, and TNFR2). |
| 3 | 18591397 | Loss of lipin 1 activity causes lipodystrophy and insulin resistance in the fld mouse, and LPIN1 expression and common genetic variation were recently suggested to influence adiposity and insulin sensitivity in humans. |
| 4 | 18693052 | Recently, pioglitazone has been reported to increase human adipocyte lipin1 expression. |
| 5 | 19799857 | PAP(1) activity was highly related with cardiac lipin-1 and lipin-3 mRNA expression in ZDF rats (r=0.99 and 0.96). |
| 6 | 19543209 | LPIN1 mRNA levels were positively correlated with PPARG and ADIPOQ mRNA levels in both VAT and SAT. |
| 7 | 19770177 | We evaluate the possibility that SIRT1 lies at the heart of a regulatory loop involving PPARalpha, PGC-1alpha (PPARA, PPARGC1A as given in the HUGO Database), and lipin-1 (LPIN1 as listed in the HUGO Database) that ultimately controls the metabolic response to varying nutrient and physiological signals via a common mechanism mediated by post-translation modifications (deacetylation) of both PPARalpha and PGC-1s. |
| 8 | 21263402 | Lipin 1 is a recently discovered multifunctional protein involved in the metabolism of lipids, while PPARgamma is involved in adipocyte differentiation, and regulation of lipid metabolism. |
| 9 | 20530740 | Our aim was to perform a cross-sectional analysis of VAT compared with subcutaneous (SAT) LPIN1 expression in a well-characterized obese cohort, its relation with the expression of genes involved in lipid metabolism, and the in vitro response to lipogenic and lipolytic stimuli. |
| 10 | 20530740 | As shown in the in vitro analysis, the low-grade proinflammatory environment and the insulin resistance associated with obesity may contribute to downregulate LPIN1 in adipose tissue, leading to a worse metabolic profile. |
| 11 | 21700896 | An acute bout of exercise, AICAR treatment, and epinephrine injections increased the mRNA levels of PGC-1?, COXIV, and lipin1 independent of decreases in nuclear RIP140 protein. |