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Gene Information
Gene symbol: MAP2K5
Gene name: mitogen-activated protein kinase kinase 5
HGNC ID: 6845
Synonyms: MEK5, MAPKK5, HsT17454
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | EDN1 | 1 hits |
| 2 | KLF2 | 1 hits |
| 3 | MAPK7 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 20628425 | Activation of ERK5 by constitutively active MEK5 (caMEK5) upregulated KLF2 and suppressed ET-1 expression in both cell lines, whereas ERK5 siRNA transfection resulted in decreased ERK5 and KLF2 and increased ET-1 mRNA expression. |
| 2 | 20671964 | On the other hand, constitutively active MEK5, an activator of ERK5, increased ERK5 activation and ERK5 and KLF2 mRNA expression and attenuated basal- and glucose-induced VEGF mRNA expression. |
| 3 | 15086914 | Finally, transfection of dominant-negative MEK5, which is an upstream regulator of BMK1, abolished the BMK1-mediated rat mesangial cell proliferation stimulated by high glucose. |