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Gene Information
Gene symbol: MAP3K14
Gene name: mitogen-activated protein kinase kinase kinase 14
HGNC ID: 6853
Synonyms: NIK, HSNIK, FTDCR1B, HS
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | ADIPOQ | 1 hits |
| 2 | ALB | 1 hits |
| 3 | CCL2 | 1 hits |
| 4 | CCL21 | 1 hits |
| 5 | FKBP4 | 1 hits |
| 6 | INS | 1 hits |
| 7 | PIK3CG | 1 hits |
| 8 | RELB | 1 hits |
| 9 | TNFSF12 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 20953353 | TWEAK promotes the secretion of MCP-1 and RANTES through NF-kappaB RelA-containing complexes and upregulates CCl21 and CCL19 expression through NF-kappaB inducing kinase (NIK-) dependent RelB/NF-kappaB2 complexes. |
| 2 | 21869881 | Since TRAF3 negatively regulates NIK expression, we silenced TRAF3 by >50%; this increased nuclear levels of p52 and RelB, and transcript levels of proinflammatory cytokines and transcription factors. |
| 3 | 21869881 | In HK-2 cells and mouse primary proximal tubule epithelial cells treated with methylglyoxal-modified albumin, multiple proinflammatory cytokines and NIK were increased in association with increased nuclear RelB and p52. |
| 4 | 21846802 | After weight loss, skeletal muscle NIK protein was significantly reduced in association with increased plasma adiponectin and enhanced AMP kinase phosphorylation and insulin sensitivity in obese subjects. |
| 5 | 21846802 | Overexpression of NIK kinase-dead dominant negative did not affect insulin-stimulated glucose uptake. |
| 6 | 21846802 | Adiponectin treatment inhibited NIK-induced NF-?B activation and restored insulin sensitivity by restoring PI3 kinase activation and subsequent Akt phosphorylation. |
| 7 | 21846802 | These results indicate that NIK induces insulin resistance and further indicate that adiponectin exerts its insulin-sensitizing effect by suppressing NIK-induced skeletal muscle inflammation. |