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Gene Information
Gene symbol: MC4R
Gene name: melanocortin 4 receptor
HGNC ID: 6932
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | AGRP | 1 hits |
| 2 | ASIP | 1 hits |
| 3 | CREB1 | 1 hits |
| 4 | INS | 1 hits |
| 5 | LEP | 1 hits |
| 6 | MC1R | 1 hits |
| 7 | MGRN1 | 1 hits |
| 8 | MLXIPL | 1 hits |
| 9 | POMC | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 11924926 | Most of these obesity disorders, with the exception of the MC4R mutations, exhibit recessive inheritance and a distinct phenotype with varying degrees of hypothalamic dysfunction, and they unravel the critical role of the central leptin and melanocortin pathways in human appetite control and energy homeostasis. |
| 2 | 19680233 | Recent genome-wide association studies (GWAS) in Asian Indians reported strong associations of variants near melanocortin-4 receptor (MC4R) and MLX interacting protein-like (MLXIPL) genes with insulin resistance and several obesity-related quantitative traits (QTs). |
| 3 | 21209091 | Surprisingly, MC4R function tested pharmacologically was normal in CREB1(?SIM1) mice, suggesting that CREB1 is not required for intact MC4R signaling. |
| 4 | 21460229 | We show that overexpression of ASP inhibits the rise in cAMP levels in response to ?-melanocyte-stimulating hormone, an MC4R agonist, by blocking ligand binding and by directing MC4R trafficking to the lysosome. |
| 5 | 21460229 | Loss-of-function of either attractin or MGRN1 blocks ASP-dependent MC4R degradation and promotes increased trafficking of internalized MC4R to the cell surface, but it does not restore ?-melanocyte-stimulating hormone-dependent cAMP signaling. |
| 6 | 11359864 | After STZ-DM induction, A(y)/a mice whose melanocortin-4 receptor (MC4-R) was blocked by ectopic expression of agouti protein additionally accelerated hyperphagia and up-regulated AGRP mRNA, implying that the mechanism is triggered by a leptin deficit rather than by the main action of the message through MC4-R. |
| 7 | 11837451 | The yellow coat colour is the result of agouti chronically antagonizing the binding of alpha-MSH to Mc1r and the obese phenotype results from agouti protein antagonizing the binding of alpha-MSH to Mc3r and/or Mc4r. |
| 8 | 11272133 | The melanocortin receptor (MC3-R and MC4-R) antagonist, agouti-related protein (AGRP), is a potent stimulant of food intake. |
| 9 | 16320160 | Agouti related protein (AgRP) is an endogenous antagonist at the MC3-R and MC4-R and is expressed in the rat adrenal cortex. |
| 10 | 18551122 | This hypothesis was reinforced after in vitro studies, using the mouse hypothalamic GT1-7 cell line, since both leptin and Norleucine(4), D-Phenylalanine(7)-alpha-MSH (NDP-alpha-MSH) treatments increased MC4-R expression. |