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Gene Information
Gene symbol: MCM8
Gene name: minichromosome maintenance complex component 8
HGNC ID: 16147
Synonyms: MGC4816, MGC12866, MGC119522, MGC119523, dJ967N21.5, REC
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CD47 | 1 hits |
| 2 | FGF2 | 1 hits |
| 3 | IGF1 | 1 hits |
| 4 | KDR | 1 hits |
| 5 | LTB4R | 1 hits |
| 6 | SERPINF1 | 1 hits |
| 7 | SHC1 | 1 hits |
| 8 | SRC | 1 hits |
| 9 | VEGFA | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 10643294 | AGEs and basic fibroblast growth factor (bFGF) induced expression of KDR in REC, and a transcription factor Sp 1 was involved in this process. |
| 2 | 17652764 | The regulation of IGF-I signaling by glucose concentration was assessed by biochemical analysis of primary RECs grown in media containing normal (5 mM) and high (25 mM) glucose. |
| 3 | 17652764 | Glucose (25 mM) enhanced the proliferative response of RECs to IGF-I. |
| 4 | 17652764 | Phosphorylation of the adaptor protein Shc (Src homology 2 domain containing) transforming protein 1) was increased in RECs grown in high glucose. |
| 5 | 17652764 | Shc recruitment to SHPS-1 was increased when RECs were grown in high glucose. |
| 6 | 17652764 | This study demonstrates that hyperglycemic conditions enhance the response of RECs to IGF-I by increasing the association of IAP with SHPS-1 permitting the formation of the SHPS-1-Shc signaling complex, which is required for the proliferative response to IGF-I. |
| 7 | 19834040 | Antagonism of the BLT1 receptor inhibited LTB(4)-induced mREC cell death. |
| 8 | 19657716 | Further studies using RECs transfected with constitutively active and dominant-negative forms of Akt suggest that PEDF could inhibit VEGF- and also Epo-induced angiogenesis by disruption of PI3K/Akt signaling. |