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Gene Information
Gene symbol: MTNR1B
Gene name: melatonin receptor 1B
HGNC ID: 7464
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | INS | 1 hits |
| 2 | MTNR1A | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 20185807 | Abnormalities in early insulin secretion were suggested in glucose-raising allele carriers at MTNR1B, GCK, FADS1, DGKB, and PROX1 (lower insulinogenic index; no association with proinsulin or insulin sensitivity). |
| 2 | 21355877 | MT1 is expressed in ?-cells while MT2 is located to the ?-cells. |
| 3 | 21585522 | On the basis of a specific radioimmunoassay, insulin secretion was found to be more strongly reduced in the clones expressing hMT2 than in INS-1 controls, when incubated with 1 or 100 nm melatonin. |
| 4 | 21711391 | Previously reported association between MTNR1B variants (rs10830963, rs4753426) and oral glucose tolerance test-derived indices of ?-cell function (homeostasis model assessment-B, P = 3.7 × 10?? and P = 0.004, respectively), as well as insulin (fasting insulin: P=2×10?³ and P=0.02; 30-min insulin: P = 2.1 × 10?? and P=0.03, respectively) and fasting glucose (rs10830963, P=1.2×10??) parameters could be replicated in the present study. |