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Gene Information
Gene symbol: MYLK
Gene name: myosin light chain kinase
HGNC ID: 7590
Synonyms: MLCK, smMLCK, MYLK1, MLCK1
Related Genes
Related Sentences
# |
PMID |
Sentence |
1 |
1418832
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The intracellular Ca-dependent protein kinase C and myosin light chain kinase activities on the phosphorylation of endogenous p47 and p20 proteins studied after 2 min of thrombin addition decreased only 10 to 25% in the presence of 5 to 10 mmol/L Mg.
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2 |
7515882
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ML-9, a myosin light chain kinase inhibitor, blocked the effects of insulin and TPA on both MAPK and PP-1 activation.
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3 |
18319547
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This effect of NO-1886 was dependent on extracellular Ca(2+) and intracellular myosin light chain kinase activity.
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4 |
20110336
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We found that insulin resistance and agonist stimulation increased the expression and activity of MMPs (MMP-2 and MMP-7), the EGFR, contractile proteins such as myosin light chain kinase and MLC II, and their transcriptional activators including P90 ribosomal kinase (P90RSK) and serum response factor, possibly via the activation of extracellular signal-regulated kinase (ERK1/2) in VSMCs.
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5 |
20479130
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Myosin light chain kinase (MLCK) plays an important role in maintaining the equilibrium by phosphorylating myosin light chain (MLC), thereby inducing actomyosin contractility and weakening endothelial cell-cell adhesion.
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