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Gene Information
Gene symbol: NKX6-1
Gene name: NK6 homeobox 1
HGNC ID: 7839
Synonyms: Nkx6.1
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | ABCC8 | 1 hits |
| 2 | HNF1A | 1 hits |
| 3 | INS | 1 hits |
| 4 | KCNJ11 | 1 hits |
| 5 | PDX1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 16873704 | We examined the association of variants in genes encoding several transcription factors (TCF1, TCF2, HNF4A, ISL1, IPF1, NEUROG3, PAX6, NKX2-2, NKX6-1, and NEUROD1) and genes encoding the ATP-sensitive K(+) channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) with type 2 diabetes in a Japanese cohort of 2,834 subjects. |
| 2 | 19264802 | Glis3 also may indirectly affect insulin promoter activity through upregulation of MafA and downregulation of Nkx6-1. |
| 3 | 20106981 | Site-directed mutagenesis of the NKX6.1 core-binding sequence eliminated NKX6.1-mediated activation and substantially decreased activity of the HNF1alpha promoter in beta cells. |
| 4 | 17131142 | The PDX1-transduced hepatocytes expressed several pancreatic transcription factors related to early pancreatic endocrine development (endogenous Pdx1, neurogenic differentiation factor 1 [Neurod1], and NK6 transcription factor related, locus 1 [Nkx6-1]) as well as the late-stage pancreatic transcription factors (paired box gene 4 [Pax4], paired box gene 6 [Pax6], and v-maf musculoaponeurotic fibrosarcoma oncogene homolog A [Mafa]). |