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Gene Information
Gene symbol: NLRP3
Gene name: NLR family, pyrin domain containing 3
HGNC ID: 16400
Synonyms: AGTAVPRL, AII, AVP, FCAS, FCU, NALP3, PYPAF1, MWS, CLR1.1
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | IL18 | 1 hits |
| 2 | INS | 1 hits |
| 3 | NPTX2 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 21862613 | Our previous studies demonstrated that the ceramides activate the Nod-like receptor family, pyrin domain containing 3 (Nlrp3) inflammasome to cause the generation of mature IL-1? and ablation of the Nlrp3 inflammasome in diet-induced obesity improves insulin signaling. |
| 2 | 1282720 | One interesting question still to be addressed is how a mutation in the NP-II coding region of this gene prevents AVP release from the posterior pituitary in the rat or the human disease. |
| 3 | 21217695 | We show that calorie restriction and exercise-mediated weight loss in obese individuals with type 2 diabetes is associated with a reduction in adipose tissue expression of Nlrp3 as well as with decreased inflammation and improved insulin sensitivity. |
| 4 | 21217695 | Ablation of Nlrp3 in mice prevents obesity-induced inflammasome activation in fat depots and liver as well as enhances insulin signaling. |
| 5 | 21217695 | Furthermore, elimination of Nlrp3 in obese mice reduces IL-18 and adipose tissue interferon-? (IFN-?) expression, increases naive T cell numbers and reduces effector T cell numbers in adipose tissue. |
| 6 | 21217695 | Collectively, these data establish that the Nlrp3 inflammasome senses obesity-associated danger signals and contributes to obesity-induced inflammation and insulin resistance. |