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Gene Information
Gene symbol: PCSK2
Gene name: proprotein convertase subtilisin/kexin type 2
HGNC ID: 8744
Synonyms: PC2, SPC2
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | GCG | 1 hits |
| 2 | INS | 1 hits |
| 3 | PSMD9 | 1 hits |
| 4 | SP1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 7698505 | Proinsulin is converted to insulin by the concerted action of two sequence-specific subtilisin-like proteases termed prohormone convertase 2 (PC2) and prohormone convertase 3. |
| 2 | 8666140 | Proinsulin is converted to insulin by the concerted action of two sequence-specific subtilisin-like proteases termed prohormone convertase 2 (PC2) and prohormone convertase 3 (PC3). |
| 3 | 17698597 | Expression of PC1/3 rather than PC2 in alpha-cells induces GLP-1 and GLP-2 production and converts the alpha-cell from a hyperglycemia-promoting cell to one that lowers blood glucose levels and promotes islet survival. |
| 4 | 19364070 | In conclusion, diabetic nude mice transplanted with human islets showed disproportionate hyperproinsulinemia and graft evidence of beta-cell restricted PC2 depletion, amyloid deposition and beta-cell death, and lack of beta-cell replication with nuclear translocation of p27(Kip1) and p21(WAF1) that together may contribute to delayed graft failure. |
| 5 | 7983775 | The promoter region of the PC2 gene is very G + C rich and contains six potential Sp1 binding sites but no TATA or CAAT box. |
| 6 | 21824269 | As both Pcsk2(-/-) and Gcgr(-/-) mice exhibit increased production of glucagon-like peptide-1 (GLP-1), which is absent in Gcg(gfp/gfp), GLP-1 is the likely cause of the difference in metabolic impact of glucagon deficiency in these animal models. |
| 7 | 21795304 | Proglucagon is cleaved to glucagon by prohormone convertase 2 (PC2) in pancreatic ?-cells, but is cleaved to glucagon-like peptide-1 (GLP-1) by PC1 in intestinal L-cells. |
| 8 | 21437630 | To investigate whether the single nucleotide polymorphisms (SNPs) of TCF7L2, SLC30A8, PCSK1 and PCSK2 were associated with T2DM as well as with proinsulin conversion in a Han Chinese population from Chongqing. |