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Gene Information
Gene symbol: PIK3C2A
Gene name: phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha
HGNC ID: 8971
Synonyms: PI3K-C2alpha
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | FOS | 1 hits |
| 2 | GCK | 1 hits |
| 3 | INS | 1 hits |
| 4 | PIK3CA | 1 hits |
| 5 | SLC2A4 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 17264162 | Moreover, glucokinase gene up-regulation requires the integrity of the juxtamembrane IR-B NPEY-motif and signaling via PI3K-C2alpha-like/PDK1/PKB, while c-fos gene activation requires the intact C-terminal YTHM-motif and signaling via PI3K Ia/Shc/MEK1/ERK. |
| 2 | 17644513 | By metabolic labeling, we here identify phosphatidylinositol 3-phosphate as the sole in vivo product of the insulin-dependent activation of PI3K-C2alpha, confirming the emerging role of such a phosphoinositide in signaling. |
| 3 | 17644513 | This is the first report showing a membrane targeting-mediated mechanism of activation for PI3K-C2alpha and that a small GTP-binding protein can activate a class II PI3K isoform. |
| 4 | 17644513 | We also demonstrate that PI3K-C2alpha contributes to maximal insulin-induced translocation of the glucose transporter GLUT4 to the plasma membrane and subsequent glucose uptake, definitely assessing the role of this enzyme in insulin signaling. |
| 5 | 20061534 | By applying pharmacological inhibitors, transient overexpression and small-interfering RNA-based knockdown of PI3K and PKB/Akt isoforms, together with PI-lipid profiling and live-cell confocal and total internal reflection fluorescence microscopy, we now demonstrate that in response to insulin, PI3K-C2alpha generates PI(3,4)P(2), which allows the selective activation of PKBalpha/Akt1. |
| 6 | 20061534 | Knockdown of PI3K-C2alpha expression and subsequent reduction of PKBalpha/Akt1 activity in the pancreatic beta-cell impaired glucose-stimulated insulin release, at least in part, due to reduced glucokinase expression and increased AS160 activity. |
| 7 | 20061534 | Hence, our results identify signal transduction via PI3K-C2alpha as a novel pathway whereby insulin activates PKB/Akt and thus discloses PI3K-C2alpha as a potential drugable target in type 2 diabetes. |