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Gene Information
Gene symbol: PPP1R13B
Gene name: protein phosphatase 1, regulatory subunit 13B
HGNC ID: 14950
Synonyms: p53BP2-like, KIAA0771, p85, ASPP1
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | AKT1 | 1 hits |
| 2 | ANK3 | 1 hits |
| 3 | CNTNAP1 | 1 hits |
| 4 | INS | 1 hits |
| 5 | IRS1 | 1 hits |
| 6 | IRS2 | 1 hits |
| 7 | MAPK1 | 1 hits |
| 8 | MAPK10 | 1 hits |
| 9 | PTK2 | 1 hits |
| 10 | PTK2B | 1 hits |
| 11 | RBP4 | 1 hits |
| 12 | SHC1 | 1 hits |
| 13 | SOCS3 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 1380182 | By contrast, insulin stimulation of the p85 Rsk S6 kinase and mitogen-activated protein (MAP) kinase activity were unaffected by drug. |
| 2 | 1382584 | Moreover, the phosphatidylinositol 3'-kinase and its 85-kDa associated protein (p85) bound to IRS-1 in Fao cells, but weakly or not at all to HMW-pp185. |
| 3 | 8384986 | Treatment of cells with IGF-I activated the PtdIns 3'-kinase, suggesting that IGF-I activates the PtdIns 3'-kinase through IRS-1 binding to p85 in a manner similar to insulin. |
| 4 | 9204876 | During insulin stimulation, p85 associated with pp60(IRS3) more rapidly than with IRS-1 or IRS-2. |
| 5 | 9204876 | In mice lacking IRS-1, p85 associated more strongly with pp60(IRS3) than with IRS-2, suggesting that pp60(IRS3) provides an alternate pathway in these cells. |
| 6 | 9204876 | Synthetic peptides containing two phosphorylated YMPM motifs displace pp60(IRS3) and IRS-1 from alphap85 immune complexes, suggesting that pp60(IRS3), like IRS-1, engages both SH2 domains in p85. |
| 7 | 15161761 | In SH-SY5Y cells, only the combination of insulin and C-peptide normalized posttranslational O-linked N-acetylglucosamine modifications and maximized serine phosphorylation of ankyrin(G) and p85 binding to caspr. |
| 8 | 16505233 | Overexpression of SOCS3 in adipocytes decreases IRS1 protein levels and subsequent insulin-stimulated IRS-1 and -2 phosphorylation, decreases p85 binding to IRS-1, and leads to decreased insulin-stimulated glucose uptake in adipocytes. |
| 9 | 20573722 | Glucagon secretion, insulin and IGF-IR autophosphorylation, and insulin receptor substrate (IRS)-1, IRS-2, phosphatidylinositol kinase (PI3K) (p85 alpha), and serine-threonine protein kinase (Akt) phosphorylated (active) forms were measured. |
| 10 | 19816414 | Further, in T2DM, serum RBP4 was correlated with p85 expression (r = 0.68, P = 0.01), and adipose RBP4 protein trended toward an association with p85 protein (r = 0.55, P = 0.06). |
| 11 | 21647634 | After the application of anti-STEAP4 antibodies at 0.002 mg/mL, adipocytes exhibited reduced insulin-stimulated glucose transport by attenuating the phosphorylation of IRS-1, PI3K (p85), and Akt. |
| 12 | 16713446 | CCK stimulated an association of Lyn with PKC-delta, Shc, p125(FAK) and PYK2 as well as with their autophosphorylated forms, but not with Cbl, p85, p130(CAS) or ERK 1/2. |