About

Home

Introduction

Statistics

Programs

Dignet

Gene

GenePair

Help & Docs

Documents

Help

FAQs

Links

Acknowledge

Disclaimer

Contact Us

Gene Information

Gene symbol: PTGDS

Gene name: prostaglandin D2 synthase 21kDa (brain)

HGNC ID: 9592

Synonyms: PGDS, L-PGDS

Related Genes

#	Gene Symbol	Number of hits
1	BCL2L1	1 hits
2	CCND1	1 hits
3	CCND3	1 hits
4	CDKN1A	1 hits
5	GSK3B	1 hits
6	INS	1 hits
7	MAPK1	1 hits
8	SLC2A1	1 hits

Related Sentences

#	PMID	Sentence
1	15240344	In wild-type VSMCs, exogenously added L-PGDS delayed serum-induced cell cycle progression from the G1 to S phase, as determined by gene array analysis and the decreased protein expressions of cyclin-dependent kinase-2, p21(Cip1), and cyclin D1.
2	15240344	Cyclin D3 protein expression was unaffected by L-PGDS, although its gene expression was stimulated by L-PGDS in wild-type cells.
3	18619553	There was however, an increase in GLUT1 expression as well as a 3-fold increase in hexokinase III expression, which was increased to nearly 5-fold in the presence of insulin, in response to L-PGDS at 20 mM glucose.
4	21104585	The lipocalins retinol-binding protein (RBP)-4, lipocalin-2 and lipocalin-type prostaglandin D-synthase (L-PGDS) have been suggested to mediate obesity-associated insulin resistance and other metabolic co-morbidities.
5	12684506	L-PGDS (50 microg/ml) was able to significantly inhibit VSMC proliferation and DNA synthesis and induce the apoptotic genes bax, bcl-x, and ei24 in SHR but had no effect on WKY cells.
6	12684506	Furthermore, we examined the effect of L-PGDS incubation on insulin-stimulated Akt, glycogen synthase kinase-3beta (GSK-3beta), and ERK phosphorylation.
7	12684506	Unexpectedly, we found that when WKY cells were pretreated with L-PGDS, insulin could actually induce apoptosis and failed to stimulate Akt/GSK-3beta phosphorylation.
8	12684506	Insulin-stimulated ERK phosphorylation was unaffected by L-PGDS pretreatment in both cell lines.