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Gene Information
Gene symbol: PTGIS
Gene name: prostaglandin I2 (prostacyclin) synthase
HGNC ID: 9603
Synonyms: PGIS, CYP8A1
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | COX8A | 1 hits |
| 2 | NOS2A | 1 hits |
| 3 | NOS3 | 1 hits |
| 4 | SOD1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 15983217 | Immunoblots showed a 73% reduction in PGI2 synthase (PGIS) expression in ZDF vessels compared with lean vessels, and there was no change in cyclooxygenase (COX) and BK channel expressions. |
| 2 | 17065353 | Concurrent administration of polyethylene-glycolated superoxide dismutase (SOD), l-nitroarginine methyl ester, or sepiapterin not only reversed the effects of high glucose on both angiotensin II-induced relaxation and PGI(2) release but also abolished high-glucose-enhanced PGIS nitration, as well as its association with eNOS. |
| 3 | 22015457 | Administration of superoxide dismutase (to scavenge superoxide anions) or l-N(G)-nitroarginine methyl ester (l-NAME, a nonselective nitric oxide synthase inhibitor) restored PGIS activity and attenuated pericyte apoptosis. |