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Gene Information
Gene symbol: TGFBR1
Gene name: transforming growth factor, beta receptor 1
HGNC ID: 11772
Synonyms: ALK-5, ACVRLK4
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | ACVRL1 | 1 hits |
| 2 | ALPP | 1 hits |
| 3 | ENG | 1 hits |
| 4 | MAPK14 | 1 hits |
| 5 | PIK3CA | 1 hits |
| 6 | TSPYL2 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 19539633 | Incubation with high glucose (HG) and glycated albumin (gAlb) induces Alk5 and raises TGFbeta secretion 3-fold without affecting Alk1 or endoglin levels. |
| 2 | 19582775 | In contrast, MC3T3-E1 cell clones in which wild-type Smad3 was stably expressed exhibited increased ALP activity and mineralization that were decreased by the ALK5 inhibitor, SB431542, although the beta-catenin levels induced in these cells were not modulated. |
| 3 | 19847393 | CDA1 overproduction increased and Tspyl2 knockdown decreased expression of TGF-beta receptor type I, TbetarI (also known as Tgfbr1), but not TGF-beta receptor type II, TbetarII (also known as Tgfbr2), providing a mechanism for CDA1's action in modulating TGF-beta signalling. |
| 4 | 21478266 | The current study provides novel insights into the molecular mechanisms of TGF-?1-induced monocyte migration, requiring ALK5 kinase activity and signalling via PI3K and p38. |