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Gene Information
Gene symbol: TLR5
Gene name: toll-like receptor 5
HGNC ID: 11851
Synonyms: TIL3, SLEB1, FLJ10052, MGC126430, MGC126431
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | INS | 1 hits |
| 2 | TLR2 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 21985371 | We have found that the expression of TLR5 is up-regulated by glucose activation of isolated islets of Langerhans, in contrast to other investigated TLRs (TLR-2, -3, -4, -6 and -9. |
| 2 | 21985371 | Activation of TLR-5 in islets lead to a marked reduction of both stimulated and basal secretion of insulin, as well as an increase in production of nitric oxide, proinflammatory cytokines, anti-inflammatory heat-shock protein and major histocompatibility complex (MHC) class I transporter. |
| 3 | 21985371 | We suggest that this regulation by TLR-5 might be beneficial during serious infection such as sepsis by limiting the activity of beta cells during peaks of insulin demand to counteract beta cell damage. |