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Gene Information
Gene symbol: TSC1
Gene name: tuberous sclerosis 1
HGNC ID: 12362
Synonyms: KIAA0243, LAM, hamartin
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | APOBEC3G | 1 hits |
| 2 | CCL26 | 1 hits |
| 3 | CRTC1 | 1 hits |
| 4 | SLC2A1 | 1 hits |
| 5 | TSC2 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 19286253 | The genes TSC1 and TSC2, encoding hamartin and tuberin, respectively, have been shown to be involved in the development of the autosomal dominantly inherited tumor syndrome tuberous sclerosis (TSC). |
| 2 | 18926585 | Tuberous sclerosis complex (TSC) gene products, TSC1 and TSC2 are tumor suppressors and specifically suppress TORC1 activity. |
| 3 | 18926585 | Mutation of either TSC1 or TSC2 causes TSC disease, which is characterized by formation of hamartomas in multiple organs. |
| 4 | 21132372 | For example, our models show that tumor sclerosis complex (TSC) inhibitors may be more effective than the rapamycin (mTOR) inhibitors currently used to treat cancer, that HIV infection could be more effectively blocked by increasing production of the human innate immune response protein APOBEC3G, rather than targeting HIV's viral infectivity factor (Vif), and how peroxisome proliferator-activated receptor alpha (PPAR?) agonists used to treat dyslipidemia would most effectively stimulate PPAR? signaling if drug design were to increase agonist nucleoplasmic concentration, as opposed to increasing agonist binding affinity for PPAR?. |
| 5 | 21613414 | In cells lacking functional tuberous sclerosis complex (TSC) 2, GLUT1 effects on mTOR activity persisted, indicating that GLUT1 effects were not mediated by TSC. |