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Gene Information
Gene symbol: UBC
Gene name: ubiquitin C
HGNC ID: 12468
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | FBXO32 | 1 hits |
| 2 | FOXO3 | 1 hits |
| 3 | IRS1 | 1 hits |
| 4 | RPS27A | 1 hits |
| 5 | SP1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 16954342 | Electrophoretic mobility shift assays and in vivo genomic footprinting demonstrated that insulin deficiency increased Sp1 binding to GC-rich elements in the UbC promoter. |
| 2 | 16954342 | Thus glucocorticoids increase UbC transcription by a mechanism involving Sp1 that is unique to muscle. |
| 3 | 20371624 | The PI3K/Akt pathway inhibits the FOXO-mediated transcription of the muscle-specific E3 ligase atrogin-1/MAFbx (AT-1), whereas the MEK/ERK pathway increases Sp1 activity and ubiquitin (UbC) expression. |
| 4 | 20371624 | We tested a signaling model in which FOXO3a mediates crosstalk between the PI3K/Akt and MEK/ERK pathways to coordinate AT-1 and UbC expression. |
| 5 | 20371624 | Knockdown of IRS-1 using small interfering RNA or adenovirus-mediated expression of constitutively activated FOXO3a increased IRS-2 protein, MEK/ERK signaling, and UbC expression. |
| 6 | 20371624 | IRS-1 and Akt phosphorylation were decreased, whereas MEK/ERK signaling and expression of IRS-2, UbC and AT-1 were increased. |