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Gene Information
Gene symbol: VDR
Gene name: vitamin D (1,25- dihydroxyvitamin D3) receptor
HGNC ID: 12679
Synonyms: NR1I1
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | ACE | 1 hits |
| 2 | APOE | 1 hits |
| 3 | CCL2 | 1 hits |
| 4 | CD34 | 1 hits |
| 5 | CD36 | 1 hits |
| 6 | IGFBP1 | 1 hits |
| 7 | INS | 1 hits |
| 8 | INSIG2 | 1 hits |
| 9 | JUN | 1 hits |
| 10 | MED1 | 1 hits |
| 11 | NPPA | 1 hits |
| 12 | PROM1 | 1 hits |
| 13 | RXRA | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 15528275 | Herein, we identified a novel 1alpha,25-dihydroxyvitamin D3 [1,25-(OH)2D3] response element in the promoter region of Insig-2 gene, which specifically binds to the heterodimer of retinoid X receptor and vitamin D receptor (VDR) and directs VDR-mediated transcriptional activation in a 1,25-(OH)2D3-dependent manner. |
| 2 | 15837528 | We have shown previously that the liganded vitamin D receptor (VDR) inhibits hypertrophy and expression of hypertrophy-sensitive genes (i.e. those encoding atrial natriuretic peptide [ANP], brain natriuretic peptide and alpha skeletal actin) in neonatal cardiac myocytes. |
| 3 | 15837528 | Conventional deletion analysis demonstrated that the promoter region positioned between -217 and -104 is required for the VDR-dependent suppression of the hANP promoter. |
| 4 | 16883034 | Vitamin D deficiency/insensitivity induces type 2 diabetes through impaired insulin secretion involving VDR on pancreatic beta cells, as well as type 1 diabetes through the reduction in immuno-modulatory action of 1,25 (OH)(2) vitamin D. |
| 5 | 17507908 | In primary MCs prepared from vitamin D receptor knockout animals, basal MCP-1 levels were elevated but not affected by 1,25(OH)2D3. |
| 6 | 20711952 | Vitamin D stimulates ovarian steroidogenesis and IGFBP-1 production in human ovarian cells likely acting via vitamin D receptor. |
| 7 | 19667238 | Conversely, deletion of the vitamin D receptor in macrophages from diabetic patients accelerated foam cell formation induced by modified LDL. 1,25(OH)(2)D(3) downregulation of c-Jun N-terminal kinase activation reduced peroxisome proliferated-activated receptor-gamma expression, suppressed CD36 expression, and prevented oxidized low-density lipoprotein-derived cholesterol uptake. |
| 8 | 21803771 | ChIP assays showed that, upon 1,25(OH)(2)D(3) activation, VDR bound to this VDRE leading to recruitment of DRIP205 and RNA polymerase II and histone 4 acetylation. |
| 9 | 21757895 | In our dialysis patients, the parameters studied on both CD34+/CD133+/KDR+ and CD34+/CD133-/KDR+ cells, in particular VDR expression, seem to be influenced by uremia-related factors, including anemia, inflammation, diabetes, 25(OH)D serum levels and calcitriol therapy. |
| 10 | 22028967 | The VDR FokI ff genotype was associated with an increase in WML (no association for APOE or ACE). |
| 11 | 21952242 | Feeding a high-lactose calcium rescue diet that circumvents a VDR requirement for calcium absorption from the intestine normalized serum calcium levels, restored ?-cell insulin secretion, corrected glucose intolerance, and eliminated accelerated T1D in VDR-deficient NOD mice. |